Complement and granulocyte activation in two different types of heparinized extracorporeal circuits Eivind Øvrum, MDa, Tom Eirik Mollnes, MD, PhDb, Erik.

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Presentation transcript:

Complement and granulocyte activation in two different types of heparinized extracorporeal circuits Eivind Øvrum, MDa, Tom Eirik Mollnes, MD, PhDb, Erik Fosse, MD, PhDc, Einfrid Åm Holen, MDa, Geir Tangen, MDa, Michel Abdelnoor, MPH, PhDa, Mari-Anne L. Ringdal, CCPa, Rolf Øystese, CCPa, Per Venge, MD, PhDd The Journal of Thoracic and Cardiovascular Surgery Volume 110, Issue 6, Pages 1623-1632 (December 1995) DOI: 10.1016/S0022-5223(95)70023-4 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Perioperative ACT in the two heparin-coated groups. Significant differences (*p < 0.001, **p < 0.01) were observed during CPB. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1623-1632DOI: (10.1016/S0022-5223(95)70023-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Perioperative plasma concentration of heparin in the two heparin-coated groups. X-clamp, Crossclamp. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1623-1632DOI: (10.1016/S0022-5223(95)70023-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Time-dependent plasma concentration of the C3 activation products in all groups. X-clamp, Crossclamp. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1623-1632DOI: (10.1016/S0022-5223(95)70023-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 7 Maximal increase of the activation markers during the operation in the four groups. The levels were significantly lower in the CBAS group than in the Duraflo II group for C3 activation products (C3bc) (*p = 0.003), and for the SC5b-9 TCC (**p < 0.001). There were marginal differences forlactoferrin (Lacto) (p = 0.05), but no difference for myeloperoxidase (MPO). See Table IV for further intergroup differences. Median values with quartiles. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1623-1632DOI: (10.1016/S0022-5223(95)70023-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 Time-dependent plasma concentration of SC5b-9 TCC in all groups. X-clamp, Crossclamp. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1623-1632DOI: (10.1016/S0022-5223(95)70023-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 5 Time-dependent plasma concentration of lactoferrin in all groups. X-clamp, Crossclamp. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1623-1632DOI: (10.1016/S0022-5223(95)70023-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 6 Time-dependent plasma concentration of myeloperoxidase in all groups. X-clamp, Crossclamp. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1623-1632DOI: (10.1016/S0022-5223(95)70023-4) Copyright © 1995 Mosby, Inc. Terms and Conditions