Ugursay Kiziltepe, MD, N. Nilufer D Turan, PhD, Unsal Han, MD, A

Slides:

Advertisements

Similar presentations

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Advertisements

Role of nitric oxide and tumor necrosis factor on lung injury caused by ischemia/reperfusion of the lower extremities Apostolos K. Tassiopoulos, MD,

Interruption of spinal cord microglial signaling by alpha-2 agonist dexmedetomidine in a murine model of delayed paraplegia Marshall T. Bell, MD, Viktor.

Without prejudice Journal of Vascular Surgery

Jeanwan Kang, MD, Hassan Albadawi, MD, Patrick J. Casey, MD, Thomas A

In vivo electroporation of constitutively expressed HIF-1α plasmid DNA improves neovascularization in a mouse model of limb ischemia Geoffrey O. Ouma,

Inhibition of micro-ribonucleic acid-320 attenuates neurologic injuries after spinal cord ischemia Fang He, MD, Enyi Shi, MD, PhD, Lihui Yan, MD, Juchen.

Early ischemic preconditioning without hypotension prevents spinal cord injury caused by descending thoracic aortic occlusion Ioannis K. Toumpoulis,

Superiority of early relative to late ischemic preconditioning in spinal cord protection after descending thoracic aortic occlusion Ioannis K. Toumpoulis,

Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia Enyi Shi, MD, PhD, Xiaojing.

DNA damage and repair system in spinal cord ischemia

Ischemic postconditioning protects the spinal cord from ischemia–reperfusion injury via modulation of redox signaling Wenying Song, MD, Jing Sun, MD,

Intrathecal transplantation of bone marrow stromal cells attenuates blood-spinal cord barrier disruption induced by spinal cord ischemia-reperfusion injury.

Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice Bao-Ngoc Nguyen, MD, Hassan Albadawi, MD, Rahmi Oklu,

Transcutaneous near-infrared spectroscopy for detection of regional spinal ischemia during intercostal artery ligation: Preliminary experimental results

Reduction of ischemic spinal cord injury by dextrorphan: Comparison of several methods of administration Hitoshi Terada, MD, Teruhisa Kazui, MD, Makoto.

Protective use of N-methyl-d-aspartate receptor antagonists as a spinoplegia against excitatory amino acid neurotoxicity Yasunori Cho, MD, Toshihiko.

Extracorporeal circulation increases proliferation in the intestinal mucosa in a large animal model Paula Rosalie Keschenau, MD, Stefanie Ribbe, Miriam.

Ryan M. McEnaney, MD, Ankur Shukla, MD, Michael C

Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits Hironori Baba, MD, Yoshihisa Tanoue, MD, PhD, Taketoshi.

Loic Lang-Lazdunski, MDa,b. , Catherine Heurteaux, PhDb

Protection of rat spinal cord from ischemia with dextrorphan and cycloheximide: Effects on necrosis and apoptosis Hiroyuki Kato, MD, PhDa c, Georgios.

The adverse effect of back-bleeding from lumbar arteries on spinal cord pathophysiology in a rabbit model Yujiro Kawanishi, MD, Kenji Okada, MD, Hiroshi.

Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury Lihong Fan, MD, Kunzheng.

Prevention of ischemic spinal cord injury: Comparative effects of magnesium sulfate and riluzole Loïc Lang-Lazdunski, MD, Catherine Heurteaux, PhD, Hervé.

Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion Patrick.

Omar Araim, MD, James Ballantyne, Andrew L. Waterhouse, PhD, Bauer E

Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats Loïc Lang-Lazdunski, MD, PhD, Nicolas Blondeau,

Experimental study on the protective effects of edaravone against ischemic spinal cord injury Kazuchika Suzuki, MD, Teruhisa Kazui, MD, PhD, Hitoshi.

Role of nitric oxide and tumor necrosis factor on lung injury caused by ischemia/reperfusion of the lower extremities Apostolos K. Tassiopoulos, MD,

Prevention of paraplegia in pigs by selective segmental artery perfusion during aortic cross-clamping Sven A. Meylaerts, MDa, Peter de Haan, MD, PhDb,

Cold spinoplegia and transvertebral cooling pad reduce spinal cord injury during thoracoabdominal aortic surgery Mitsuhiro Isaka, MD, Hajime Kumagai,

The neuroprotective effects of intrathecal administration of the selective N-type calcium channel blocker ziconotide in a rat model of spinal ischemia

Neuroprotection following mild hypothermia after spinal cord ischemia in rats Takeshi Saito, PhD, Shino Saito, MD, Hiroshi Yamamoto, MD, PhD, Masanori.

Without prejudice Journal of Vascular Surgery

Insulin-like growth factor 1 prevents neuronal cell death and paraplegia in the rabbit model of spinal cord ischemia Yoshihisa Nakao, MD, Hajime Otani,

Protecting the brain and spinal cord

Paraganglioma of the hypoglossal nerve

Neuronal Cell Death in the Ischemic Spinal Cord: The Effect of Methylprednisolone Georgios K. Kanellopoulos, MD, Hiroyuki Kato, MD, PhD, Yingji Wu, MSc,

Interleukin-1 receptor antagonist attenuates the severity of spinal cord ischemic injury in rabbits Satoshi Akuzawa, MD, Teruhisa Kazui, MD, PhD, Enyi.

Autophagy-mediated stress response in motor neurons after hypothermic spinal cord ischemia in rabbits Satoshi Fujita, MD, Masahiro Sakurai, MD, PhD,

Inhibition of MicroRNA-204 Conducts Neuroprotection Against Spinal Cord Ischemia Lihui Yan, MD, Enyi Shi, MD, PhD, Xiaojing Jiang, MD, PhD, Jiang Shi,

David A. Zvara, MD, David M. Colonna, MD, Dwight D. Deal, BS, Jason C

The best of times, the worst of times…

Dose-dependent neuroprotection of delta-opioid peptide [D-Ala2, D-Leu5] enkephalin on spinal cord ischemia-reperfusion injury by regional perfusion into.

Effects of carbamazepine on spinal cord ischemia

Shadi J. Abu-Halimah Journal of Vascular Surgery

Spinal cord injury in experimental thoracic aortic occlusion: investigation of combined methods of protection James R. Elmore, MD, Peter Gloviczki, MD,

A peroxisome proliferator-activated receptor gamma agonist attenuates neurological deficits following spinal cord ischemia in rats Hyunchang Kim, MD,

Memantine for prevention of spinal cord injury in a rabbit model

New method for absolute spinal cord ischemia protection in rabbits

Masson's tumor in the ulnar artery

John Blebea, MD, Robert A. Cambria, MD, David DeFouw, PhD, Richard N

Ischemic preconditioning ameliorates spinal cord ischemia-reperfusion injury by triggering autoregulation Cheng-Loong Liang, MD, Kang Lu, MD, PhD, Po-Chou.

Autophagy-mediated stress response in motor neuron after transient ischemia in rabbits Hironori Baba, MD, Masahiro Sakurai, MD, PhD, Koji Abe, MD, PhD,

Reply Journal of Vascular Surgery

Overexpression of microRNA-21 protects spinal cords against transient ischemia Fang He, MD, PhD, Yixing Ren, MD, Enyi Shi, MD, PhD, Kun Liu, MD, Lihui.

Jon S. Matsumura, MD, Adnan Z. Rizvi, MD Journal of Vascular Surgery

Thrombotic mesenteric ischemia due to aortic dissection

Myogenic transcranial motor evoked potentials monitoring cannot always predict neurologic outcome after spinal cord ischemia in rats Manabu Kakinohana,

Daniel J. Martin, MD, Tomas D. Martin, MD, Philip J

The adenosine triphosphate–sensitive potassium channel opener nicorandil protects the ischemic rabbit spinal cord Yutaka Wakamatsu, MDa, Norihiko Shiiya,

Ischemia-reperfusion injury of the spinal cord: Protective effect of the hydroxyl radical scavenger dimethylthiourea Willem Wisselink, MD, Samuel R.

Gary W. Barone, MD, Axel W. Joob, MD, Terry L. Flanagan, MPH, Carey E

Monitoring of intrathecal oxygen tension during experimental aortic occlusion predicts ultrastructural changes in the spinal cord Anders Hellberg, MDa,

Bhagwan Satiani, MD, MBA, Thomas E. Williams, MD, PhD, Michael R

Failure of motor evoked potentials to predict neurologic outcome in experimental thoracic aortic occlusion James R. Elmore, MD, Peter Gloviczki, MD,

Cannabinoid 1 receptor mediation of spinal cord ischemic tolerance induced by limb remote ischemia preconditioning in rats Binxiao Su, MD, Hailong Dong,

Dawn M. Coleman, Amer Heider, MD, David Gordon, Santhi K

Presentation transcript:

Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury Ugursay Kiziltepe, MD, N.Nilufer D Turan, PhD, Unsal Han, MD, A.Tulga Ulus, MD, Fatma Akar, PhD Journal of Vascular Surgery Volume 40, Issue 1, Pages 138-145 (July 2004) DOI: 10.1016/j.jvs.2004.03.032

Fig 1 Histopathologic findings of anterior horn of lumbar spinal cord segments procured 48 hours after reperfusion and stained with hematoxylin-eosin. A, Normal appearance of neurons in sham operated animals (arrows, Nissl substance, ×40). B, Eosinophilic neuronal degeneration in group C, exhibiting inflammatory cell accumulation, destruction and vacuolization of the gray matter, pyknosis of neurons and capillary proliferation (single arrows, necrotic neuron bodies without Nissl substance; double arrow, new capillary vessels [neovascularization]; ×40). C, Near to normal appearance of anterior horn of lumbar spinal cord segments in group R10 with protected Nissl substance (arrows, ×400). Journal of Vascular Surgery 2004 40, 138-145DOI: (10.1016/j.jvs.2004.03.032)

Fig 1 Histopathologic findings of anterior horn of lumbar spinal cord segments procured 48 hours after reperfusion and stained with hematoxylin-eosin. A, Normal appearance of neurons in sham operated animals (arrows, Nissl substance, ×40). B, Eosinophilic neuronal degeneration in group C, exhibiting inflammatory cell accumulation, destruction and vacuolization of the gray matter, pyknosis of neurons and capillary proliferation (single arrows, necrotic neuron bodies without Nissl substance; double arrow, new capillary vessels [neovascularization]; ×40). C, Near to normal appearance of anterior horn of lumbar spinal cord segments in group R10 with protected Nissl substance (arrows, ×400). Journal of Vascular Surgery 2004 40, 138-145DOI: (10.1016/j.jvs.2004.03.032)

Fig 2 Malondialdehyde levels of lumbar spinal cord segments procured at the 48th hour of reperfusion. * P = .065, group R10 vs group S; P = .001, group R10 vs group C; P = .02, group R10 vs group R1. †P = .0005, groups R1 and R10 vs group S. Journal of Vascular Surgery 2004 40, 138-145DOI: (10.1016/j.jvs.2004.03.032)

Fig 3 Time course of nitrite/nitrate levels throughout the experiments. *NO release increased during ischemia in group R10 (P < .05 vs preischemia) whereas it decreased in group C (P < .01 vs preischemia). †When calculated absolute changes from baseline were compared, P < .05, group C vs group R; P < .01, group C vs group R10. During the postischemia phase, previously decreased NO release started to increase in group C whereas previously increased NO release decreased close to baseline values in groups R and R10 (P < .01 vs ischemia for group R). When calculated absolute changes from ischemia values were compared, P < .01, group C vs group R; P < .01, group C vs group R10. Journal of Vascular Surgery 2004 40, 138-145DOI: (10.1016/j.jvs.2004.03.032)