Adult neurogenesis ablation in the vDG but not in the dDG blocked the analgesic effect of EE-VEx in chronic inflammatory pain. Adult neurogenesis ablation.

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Adult neurogenesis ablation in the vDG but not in the dDG blocked the analgesic effect of EE-VEx in chronic inflammatory pain. Adult neurogenesis ablation in the vDG but not in the dDG blocked the analgesic effect of EE-VEx in chronic inflammatory pain. A, Diagram showing time line of experiments. Mice were housed in EE-VEx or BH after virus injection and then injected intraplantarly with saline or CFA 21 d after virus injection into dDG or vDG. Mice PWLs to thermal stimulus were measured on days 1, 3, 7, 10, 14, 17, 21, and 28 after intraplantar CFA or saline injection. B–E, Adult dDG neurogenesis ablation had limited effects on thermal pain thresholds at baseline (n = 8 in each group; B, D), after normal saline injection (n = 5 in each group; C), or after CFA injection (n = 8 in each group; E) under either BH or EE-VEx. F–I, Ablating vDG neurogenesis did not affect thermal pain thresholds at baseline (n = 8 in each group; F, H) or after normal saline injection (n = 5 in each group; G) but aggravated CFA-induced thermal hyperalgesia and blocked the analgesic effect of EE-VEx (n = 8 in each group; I). **p < 0.01, ANOVA with repeated measures and Bonferroni's post hoc test. n.s, Statistically nonsignificant. Jie Zheng et al. J. Neurosci. 2017;37:4145-4157 ©2017 by Society for Neuroscience