Prognostic Impact of Node Involvement Pattern in Pulmonary pN1 Squamous Cell Carcinoma Patients Masayuki Nakao, MD, Junji Yoshida, MD, PhD, Genichiro.

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Prognostic Impact of Node Involvement Pattern in Pulmonary pN1 Squamous Cell Carcinoma Patients Masayuki Nakao, MD, Junji Yoshida, MD, PhD, Genichiro Ishii, MD, PhD, Tomoyuki Hishida, MD, PhD, Mitsuyo Nishimura, MD, Kanji Nagai, MD, PhD Journal of Thoracic Oncology Volume 5, Issue 4, Pages 504-509 (April 2010) DOI: 10.1097/JTO.0b013e3181ccb391 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Patterns of N1 involvement according to the relationship between the main tumor and involved node on resected specimen. Macroscopic (A) and microscopic (hematoxylin and eosin; B) findings of the main tumor and “direct N1” nodes. N1 nodes are completely inside of, or partly connected to, the main tumor. Macroscopic findings of the main tumor and “separate N1” node (C) and microscopic findings of the node (hematoxylin and eosin; D). Journal of Thoracic Oncology 2010 5, 504-509DOI: (10.1097/JTO.0b013e3181ccb391) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Overall survival curves of pN0-2 pulmonary SCC patients. Overall survival curves of all pN0, pN1, and pN2 patients (A). Overall survival curves of the direct and separate N1 groups compared with pN0 and pN2 patients (B). Journal of Thoracic Oncology 2010 5, 504-509DOI: (10.1097/JTO.0b013e3181ccb391) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Stratified analysis of prognostic impact of node involvement pattern according to pathologic T classification. Overall survival curves of the direct and separate N1 groups in pT1 (A), pT2 (B), and pT3 (C) patient groups. Journal of Thoracic Oncology 2010 5, 504-509DOI: (10.1097/JTO.0b013e3181ccb391) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions