IL-10 upregulates IgG4 production by CD27+ B cells.

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Presentation transcript:

IL-10 upregulates IgG4 production by CD27+ B cells. IL-10 upregulates IgG4 production by CD27+ B cells. (A and C) IgE (A) and IgG4 (C) in culture supernatants of isolated CD27+ B cells at baseline and following addition of anti-CD40. (B and D) Fold change in levels of IgE (B) and IgG4 (D) in culture supernatants of isolated CD27+ B cells stimulated with anti-CD40 Ab and IL-4 with and without IL-10 relative to CD27+ B cells cultured with anti-CD40 Ab alone (n = 6). (E and G) IgE (E) and IgG4 (G) in culture supernatants of isolated CD27− B cells at baseline and following addition of anti-CD40. (F and H), Fold change in levels of IgGE (F) and IgG (H) in culture supernatants of isolated CD27− B cells stimulated with anti-CD40 Ab and IL-4 with and without IL-10 relative to B cells cultured with anti-CD40 Ab alone (n = 9). Each individual is represented with a unique color; colors are consistent for (A)–(H). The p values were determined using Wilcoxon matched pairs signed-rank test. Adora A. Lin et al. ImmunoHorizons 2018;2:398-406 ©2018 by American Association of Immunologists