Stavros K. Kakkos, MD, PhD, RVT, Andrew N

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Predictors and clinical significance of progression or regression of asymptomatic carotid stenosis Stavros K. Kakkos, MD, PhD, RVT, Andrew N. Nicolaides, MS, PhD, FRCS, Ioanna Charalambous, Dafydd Thomas, MD, FRCP, Argyrios Giannopoulos, MD, A. Ross Naylor, MD, FRCS, George Geroulakos, MD, PhD, Anne L. Abbott, MBBS, FRACP, PhD Journal of Vascular Surgery Volume 59, Issue 4, Pages 956-967.e1 (April 2014) DOI: 10.1016/j.jvs.2013.10.073 Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 1 Effect of significant factors in model 1 (Table IV) on progression free survival. A, Creatinine (log-rank, P < .001). B, Ipsilateral stenosis (log-rank, P overall < .001). C, Plaque area (log-rank, P = .004). D, Gender (log-rank, P < .001). E, Lipid-lowering therapy (log-rank, P = .009). Journal of Vascular Surgery 2014 59, 956-967.e1DOI: (10.1016/j.jvs.2013.10.073) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 2 Effect of significant factors in model 2 (Table IV) on occlusion-free survival. A, Effect of grayscale median (GSM; log-rank, P = .001). GSM 23 is the cutoff point between lower and middle tertiles. B, Effect of ipsilateral stenosis (log-rank, P overall < .001). C, Effect of contralateral stenosis (log-rank, P overall = .008). D, Effect of gender on occlusion-free survival (log-rank, P = .007). Journal of Vascular Surgery 2014 59, 956-967.e1DOI: (10.1016/j.jvs.2013.10.073) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 3 Effect of significant factors in model 3 (Table IV) on regression-free survival. A, Age (log-rank, P = .016). B, Ipsilateral stenosis (log-rank, P = .081). C, Lipid-lowering therapy (log-rank, P = .002). D, Presence of discrete white areas (DWAs; log-rank, P = .032). Journal of Vascular Surgery 2014 59, 956-967.e1DOI: (10.1016/j.jvs.2013.10.073) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 4 A, Effect of changes in stenosis on ipsilateral cerebrovascular or retinal ischemic (CORI) events (log-rank overall, P < .001). B, Effect of changes in stenosis on ipsilateral hemispheric stroke (log-rank overall, P = .050). Note: Only 19 strokes occurred in the group of patients that had progression of stenosis; the remaining 40 strokes occurred in the group that had no change in stenosis. Journal of Vascular Surgery 2014 59, 956-967.e1DOI: (10.1016/j.jvs.2013.10.073) Copyright © 2014 Society for Vascular Surgery Terms and Conditions