Rare Pathogenic Variants in IL36RN Underlie a Spectrum of Psoriasis-Associated Pustular Phenotypes  Niovi Setta-Kaffetzi, Alexander A. Navarini, Varsha M. Patel, Venu Pullabhatla, Andrew E. Pink, Siew-Eng Choon, Michael A. Allen, A David Burden, Christopher E.M. Griffiths, Marieke M.B. Seyger, Brian Kirby, Richard C. Trembath, Michael A. Simpson, Catherine H. Smith, Francesca Capon, Jonathan N. Barker  Journal of Investigative Dermatology  Volume 133, Issue 5, Pages 1366-1369 (May 2013) DOI: 10.1038/jid.2012.490 Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Characterization of the IL36RN variants uncovered in this study. Sequence chromatograms for each substitution are shown on the left, whereas the right end panels show the position of the relevant amino acids within the three-dimensional structure of the IL-36Ra protein. Key regions (loop 3–4, residues 30–41 and loop 7–8, residues 82–98) and amino acids (His32, Lys38, Tyr89, Glu94, Lys96) mediating the interaction of IL-36ra with its cognate receptor are highlighted. The pSer113Leu variant is not shown, as this substitution has been previously characterized (Onoufriadis et al., 2011). Journal of Investigative Dermatology 2013 133, 1366-1369DOI: (10.1038/jid.2012.490) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions