Volume 58, Issue 3, Pages 1325-1335 (September 2000) Effect of hemoglobin levels in hemodialysis patients with asymptomatic cardiomyopathy  Robert N. Foley, Patrick S. Parfrey, Janet Morgan, Paul E. Barré, Patricia Campbell, Pierre Cartier, Douglas Coyle, Adrian Fine, Paul Handa, Iris Kingma, Cathy Y. Lau, Adeera Levin, David Mendelssohn, Norman Muirhead, Brendan Murphy, Richard K. Plante, Gerald Posen, George A. Wells  Kidney International  Volume 58, Issue 3, Pages 1325-1335 (September 2000) DOI: 10.1046/j.1523-1755.2000.00289.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Weekly hemoglobin levels (A) and epoetin α doses (B) in patients with concentric left ventricular (LV) hypertrophy. Symbols are: (○) mean hemoglobin levels in the low hemoglobin target group; (•) normal hemoglobin target group. The vertical bars are 95% confidence intervals. Kidney International 2000 58, 1325-1335DOI: (10.1046/j.1523-1755.2000.00289.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Weekly hemoglobin levels (A) and epoetin α doses (B) in patients with LV dilation. Symbols are: (○) mean hemoglobin levels in the low hemoglobin target group; (•) normal hemoglobin target group. The vertical bars are 95% confidence intervals. Kidney International 2000 58, 1325-1335DOI: (10.1046/j.1523-1755.2000.00289.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 (A) Patients with concentric LV hypertrophy. Cumulative frequency distribution of the change in LV mass index from baseline to 48 weeks in the low (solid lines) and high (dotted lines) target hemoglobin groups. The groups are similar in terms of central tendency (P = 0.35 by Mann–Whitney U-test) and distribution shape (P = 0.60 by the Kolmogorov–Smirnov Z-test). (B) Patients with concentric LV hypertrophy. Change in LV mass index from baseline to 48 weeks on the Y axis plotted against mean hemoglobin levels achieved. Symbols are: (○) mean hemoglobin levels in the low hemoglobin target group; (•) normal hemoglobin target group. The correlation between the change in LV mass index and mean hemoglobin did not reach statistical significance (β coefficient -6.94 g/m2 per 1 g/dL increment in mean hemoglobin, 95% confidence interval -14.61 to 7.30 g/m2 per 1 g/dL, R = 0.24, P = 0.075). Kidney International 2000 58, 1325-1335DOI: (10.1046/j.1523-1755.2000.00289.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 (A) Patients with concentric LV hypertrophy. Cumulative frequency distribution of the change in LV cavity volume index from baseline to 48 weeks in the low (solid lines) and high (dotted lines) target hemoglobin groups. The groups are similar in terms of central tendency (P = 0.13 by the Mann–Whitney U-test) but differ in terms of distribution shape (P = 0.036 by the Kolmogorov–Smirnov Z-test). (B) Patients with concentric LV hypertrophy. Change in LV cavity volume index from baseline to 48 weeks on the Y axis plotted against mean hemoglobin levels achieved. Symbols are: mean hemoglobin levels in the low hemoglobin target group; (•) normal hemoglobin target group. The correlation between change in LV cavity volume index and mean hemoglobin was statistically significant (β coefficient -8.00 mL/m2 per 1 g/dL increment in mean hemoglobin, 95% confidence interval -13.91 to -2.09 mL/m2 per 1 g/dL, R = 0.34, P = 0.009). Kidney International 2000 58, 1325-1335DOI: (10.1046/j.1523-1755.2000.00289.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 5 (A) Patients with LV dilation. Cumulative frequency distribution of the change in LV mass index from baseline to 48 weeks in the low (solid lines) and high (dotted lines) target groups. The groups are similar in terms of central tendency (P = 0.66 by Mann–Whitney U-test) and distribution shape (P = 0.93 by the Kolmogorov–Smirnov Z-test). (B) Patients with LV dilation. Change in LV mass index from baseline to 48 weeks on the Y axis plotted against mean hemoglobin levels achieved. Symbols are: (○) mean hemoglobin levels in the low hemoglobin target group; (•) represent the normal hemoglobin target group. The correlation between the change in LV mass index and mean hemoglobin was not statistically significant (β coefficient 0.03 g/m2 per 1 g/dL increment in mean hemoglobin, 95% confidence interval -0.90 to 0.85 g/m2 per 1 g/dL, R = 0.01, P = 0.95). Kidney International 2000 58, 1325-1335DOI: (10.1046/j.1523-1755.2000.00289.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 6 (A) Patients with LV dilation. Cumulative frequency distribution of the change in LV cavity volume index from baseline to 48 weeks in the low (solid lines) and high (dotted lines) target hemoglobin groups. The groups are similar in terms of central tendency (P = 0.45 by the Mann–Whitney U-test) and distribution shape (P = 0.26 by the Kolmogorov–Smirnov Z-test). (B) Patients with LV dilation. Change in LV cavity volume index from baseline to 48 weeks on the Y axis plotted against mean hemoglobin levels achieved on the X axis. Symbols are: (○) mean hemoglobin levels in the low hemoglobin target group; (•) normal hemoglobin target group. The correlation between change in LV cavity volume index and mean hemoglobin is not statistically significant (β coefficient 0.46 mL/m2 per 1 g/dL increment in mean hemoglobin, 95% confidence interval -0.31 to 1.24 mL/m2 per 1 g/dL, R = 0.02, P = 0.24). Kidney International 2000 58, 1325-1335DOI: (10.1046/j.1523-1755.2000.00289.x) Copyright © 2000 International Society of Nephrology Terms and Conditions