Chromatin structure: Linking structure to function with histone H1

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Chromatin structure: Linking structure to function with histone H1 Jonathan Widom  Current Biology  Volume 8, Issue 22, Pages R788-R791 (November 1998) DOI: 10.1016/S0960-9822(07)00500-3

Figure 1 Interaction of GH5 DNA-binding site 1 with DNA, modeled by homology to the co-crystal structure of the related transcription factor HNF3. Binding site 1 comprises residues from helix III and an additional lysine sidechain (illustrated) from the adjacent ‘wing’ domain. Positively-charged sidechains contributing to DNA-binding site 2, on the lower surface of the protein, are shown. Serine sidechains that were mutated to cysteines and used for attachment of the crosslinker are also shown. See [5,9] for additional details. (Figure courtesy S. Muyldermans and T. Hamelrijck.) Current Biology 1998 8, R788-R791DOI: (10.1016/S0960-9822(07)00500-3)

Figure 2 Location of GH5 on a model of the nucleosome core-particle DNA superhelix, as deduced from the new study by Zhou et al. [9]. The DNA backbone at the nucleosomal dyad-symmetry axis is highlighted. The orientation of GH5 is the same as illustrated in Figure 1. (Figure courtesy S. Muyldermans and T. Hamelrijck.) Current Biology 1998 8, R788-R791DOI: (10.1016/S0960-9822(07)00500-3)