Group 3 Group 3 The “Omes” Precision Cancer Medicine Advocate Mentor: Patrick Sullivan Scientific Mentor: Camille Ragin, PhD, MPH Group Members: Ivy Elkins, Kathye D. Jenkins, David Makumi, Katie Parker, Seana Roubinek, Lanette Veres

Definitions & Application What are Omics? Definitions & Application Omics aims at the collective characterization and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms. Multi-OMICS approaches in cancer can be used to: - to dissect the cell response to chemo- or immunotherapy -discover molecular candidates with diagnostic/prognostic value.  Diverse OMICs strategies in cancer are important for better understanding of: -Cancer progression, -Discovery of new therapeutic interventions. -Development of new cancer biomarkers

Banner here Genome Epigenome Transcriptome Proteome

Tomato Potato

EGFR ALK ROS1 BRAF NTRK MET MEK Precision Medicine Success Molecular profiling has changed lung cancer treatment from a one-size-fits-all approach to targeted therapy for many mutations types, including: EGFR ALK ROS1 BRAF NTRK MET MEK

Some examples of cancers with targeted therapies Ovarian – PARP Inhibitors Breast Cancer – Herceptin CML & GIST – Gleevac

Examples of tumors that lend themselves to Precision Medicine Do Don’t Lung Hard to get at tissues Breast Some blood cancers CML Brain Melanoma

Obstacles to Precision Medicine Cost Availability Accessible Drugs Disparities Lengthy development Approval of new indications Access to clinical trials

Innovations/New Ideas Approaches that target multiple truncal mutations Single cell sequencing

Thank you for the opportunity to participate in the Scientist Survivor Program, AACR ! Love, Group 3