Volume 80, Issue 11, Pages (December 2011)

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Volume 80, Issue 11, Pages 1113-1114 (December 2011) Journal Club Kidney International Volume 80, Issue 11, Pages 1113-1114 (December 2011) DOI: 10.1038/ki.2011.367 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure KLF5 in renal collecting duct cells controls renal responses to unilateral ureteral obstruction. (a and b) Effects of bone marrow (BM)-specific Klf5 haploinsufficiency on the responses to unilateral ureteral obstruction (UUO). Wild-type mice whose BM had been replaced with either wild-type or Klf5+/− BM were subjected to either UUO or sham operation. (a) CD11b+F4/80low fractions were analyzed 24 hours after UUO. n = 5. (b) mRNA expression 24 hours after UUO. (c and d) Effects of collecting duct-specific Klf5 deletion on the response to UUO. Klf5fl/fl and Klf5fl/fl;Aqp2-Cre mice were subjected to either UUO or sham operation. (c) CD11b+F4/80low fractions were analyzed 24 hours after UUO. n = 5. *P < 0.05. (d) mRNA 24 hours after UUO. *P < 0.05. NS, not significant. Kidney International 2011 80, 1113-1114DOI: (10.1038/ki.2011.367) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure A genetic and cellular program for regeneration of the planarian protonephridia. (a) Model for protonephridia regeneration: Neoblasts (dark blue, dividing cell expressing smedwi-1 and histone H2B) produce a transient population of precursor cells (light blue) that coexpresses Six1/2-2, Eya, Osr, POU2/3, Sall, and SMEDWI-1. Some cells expressing Six1/2-2, POU2/3, and Sall expressed neoblast-specific H2B (S-phase marker) and/or smedwi-1 mRNA. The dotted box indicates that data cannot distinguish whether this precursor population is homogeneous or heterogeneous in potential. Precursor cells differentiate either as a tubule cell (green), maintaining expression of POU2/3, Sall, and Osr and expressing rootletin and cubilin, or as a tubule-associated cell (magenta), maintaining Six1/2-2 expression and expressing carbonic anhydrase (CA). (b) Schematic of the planarian protonephridial system. Genes expressed in either tubule (green and yellow), tubule-associated cells (magenta), or tubule-associated cells-2 (orange) are shown. Kidney International 2011 80, 1113-1114DOI: (10.1038/ki.2011.367) Copyright © 2011 International Society of Nephrology Terms and Conditions