A and b) Moraxella catarrhalis ubiquitous surface protein (Usp) A2 binds collagen with high affinity. a and b) Moraxella catarrhalis ubiquitous surface.

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Presentation transcript:

a and b) Moraxella catarrhalis ubiquitous surface protein (Usp) A2 binds collagen with high affinity. a and b) Moraxella catarrhalis ubiquitous surface protein (Usp) A2 binds collagen with high affinity. Transmission electron microscopy (TEM) demonstrates that a) gold-labelled recombinant UspA1 does not bind to collagen I fibrils, whereas b) UspA2 does. Reproduced and modified from [17] with permission. c) Bacterial adhesins target laminin globular domains at the base of the asymmetrical cross-shaped laminin. TEM image showing gold-labelled Protein F from nontypeable Haemophilus influenzae bound to laminin. Reproduced and modified from [31] with permission; these images are not included under the Creative Commons CC BY-NC 4.0 licence of the current article. In all panels, gold-labelled recombinant bacterial proteins are marked with white arrows. Magnus Paulsson, and Kristian Riesbeck Eur Respir Rev 2018;27:180018 ©2018 by European Respiratory Society