Local allergic reaction in food-hypersensitive adults despite a lack of systemic food- specific IgE Xiao Ping Lin, MD a, Jenny Magnusson, BSc a,b, Staffan.

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Local allergic reaction in food-hypersensitive adults despite a lack of systemic food- specific IgE Xiao Ping Lin, MD a, Jenny Magnusson, BSc a,b, Staffan Ahlstedt, PhD c, Anna Dahlman-Höglund, PhD d, Lars Å. Hanson, MD, PhD a, Olle Magnusson, MD, PhD e, Ulf Bengtsson, MD, PhD b, Esbjörn Telemo, PhD a Journal of Allergy and Clinical Immunology Volume 109, Issue 5, Pages 879-887 (May 2002) DOI: 10.1067/mai.2002.123238 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Immunostaining of duodenal biopsies from food-allergic patients and controls. Red-brown color indicates positive staining; blue color indicates counterstaining of nuclei. Black bars indicate 100 μm. A, CD3+ T cells in a nonchallenged patient without symptoms. B, Marked increase of CD3+ T cells in a challenged patient with symptoms. C, Presence of IgE-stained cells in a nonchallenged patient without symptoms. D, Enhanced presence of IgE-stained cells in a challenged patient with symptoms. E, MBP-stained eosinophils in a nonchallenged patient without symptoms; note nonspecific staining of mucus in goblet cells. F, Marked increase of MBP-stained eosinophils in a challenged patient with symptoms. G, MBP-stained eosinophils (as in Fig 1, F ) at higher magnification; note MBP-containing granules free in the tissue. H, CD3+ T cells in a control. I, IgE-stained cells in a control. J, MBP-stained eosinophils in a control. K, Isotype control staining. Journal of Allergy and Clinical Immunology 2002 109, 879-887DOI: (10.1067/mai.2002.123238) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Numbers of MBP+ eosinophils (A ), IgE-stained cells (B ), CD3+, CD4+, and CD8+ T cells (C ), IL-4-stained cells (D ), and IFN-γ-stained cells (E ) in duodenal biopsy specimens taken from healthy controls and SPT-negative/s-IgE Ab-negative patients with and without symptoms (n = 11). Results are expressed as individual data points, and the medians are indicated. Three patients with positive SPT results/positive s-IgE Ab and their healthy controls are included as references (black dots) . *P < .05. **P < .005. ***P < .001. Journal of Allergy and Clinical Immunology 2002 109, 879-887DOI: (10.1067/mai.2002.123238) Copyright © 2002 Mosby, Inc. Terms and Conditions