Fel d 1 and Fel d 4 levels in cat fur, saliva, and urine

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Presentation transcript:

Fel d 1 and Fel d 4 levels in cat fur, saliva, and urine Suzanne M. Kelly, PhD, Jacob Karsh, MD, CM, FRCPC, Jennifer Marcelo, BHSc, Douglas Boeckh, DVM, Nate Stepner, MHSc, D Litt, Bryan Santone, HBSc, MBA, Jimmy Yang, MBA, William H. Yang, MD, FRCPC Journal of Allergy and Clinical Immunology Volume 142, Issue 6, Pages 1990-1992.e3 (December 2018) DOI: 10.1016/j.jaci.2018.07.033 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Box and whisker plots of Fel d 1 and Fel d 4 levels by anatomic location. A, Fur (n = 26). B, Urine (n = 20). C, Saliva (n = 17). Box, Twenty-fifth and 75th percentiles; bars, minimum and maximum values; solid line, median values. Fel d 4 levels were less than Fel d 1 levels in fur and greater in saliva. All but 2 urine Fel d 4 samples had levels of less than the limit of detection, which was used when calculating the median. The limits of detection for Fel d 1 are 0.08 μg/g for fur and 0.002 μg/mL for saliva and urine, and there is a less than 0.01% cross-reactivity with natural Can f 1 allergen. Fel d 4 limits are 0.008 μg/g for fur and 0.0004 μg/mL for saliva and urine and less than 0.01% cross-reactivity with natural Fel d 1 allergen. Journal of Allergy and Clinical Immunology 2018 142, 1990-1992.e3DOI: (10.1016/j.jaci.2018.07.033) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Fel d 1 and Fel d 4 levels versus age in cat fur and saliva. Neither antigen varies with age. In fur Fel d 4 levels are less than Fel d 1 levels, and there is no overlap. In saliva there is considerable overlap, and the greater median values for Fel d 4 are due to a subset of cats with high levels. Journal of Allergy and Clinical Immunology 2018 142, 1990-1992.e3DOI: (10.1016/j.jaci.2018.07.033) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions