Sven Y. Surikow et al. BTS 2018;3:213-226 Immunohistochemical Effects of ISO Alone (Representative Images) Effects of ISO on 3-NT, TXNIP, and PAR expression in the myocardium. The accumulation of 3-NT is shown in (A) control rat myocardium and (B) ISO-treated myocardium. TXNIP accumulation is shown in (C) control rat myocardium and (D) ISO-treated myocardium. PAR accumulation is shown in (E) control rat myocardium and (F) ISO-treated myocardium. Abbreviations as in Figure 3. Sven Y. Surikow et al. BTS 2018;3:213-226 2018 The Authors