Incidence and Determinants of Hepatocellular Carcinoma in Autoimmune Hepatitis: A Systematic Review and Meta-analysis Aylin Tansel, Lior H. Katz, Hashem.

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Incidence and Determinants of Hepatocellular Carcinoma in Autoimmune Hepatitis: A Systematic Review and Meta-analysis Aylin Tansel, Lior H. Katz, Hashem B. El-Serag, Aaron P. Thrift, Mayur Parepally, Mohammad H. Shakhatreh, Fasiha Kanwal Clinical Gastroenterology and Hepatology Volume 15, Issue 8, Pages 1207-1217.e4 (August 2017) DOI: 10.1016/j.cgh.2017.02.006 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols flow diagram. Clinical Gastroenterology and Hepatology 2017 15, 1207-1217.e4DOI: (10.1016/j.cgh.2017.02.006) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Forest plot of incidence of HCC in patients with AIH. Incidence rate reported per 1000 person-years. Clinical Gastroenterology and Hepatology 2017 15, 1207-1217.e4DOI: (10.1016/j.cgh.2017.02.006) Copyright © 2017 AGA Institute Terms and Conditions

Figure 3 (A) Forest plot of incidence of HCC in patients with AIH with cirrhosis at baseline. Incidence rate reported per 1000 person-years. (B) Forest plot of incidence of HCC in patients with AIH without cirrhosis at baseline. Incidence rate reported per 1000 person-years. Clinical Gastroenterology and Hepatology 2017 15, 1207-1217.e4DOI: (10.1016/j.cgh.2017.02.006) Copyright © 2017 AGA Institute Terms and Conditions

Figure 4 (A) Forest plot of incidence of HCC in patients with AIH by sex. Incidence rate reported per 1000 person-years. (B) Forest plot of incidence of HCC in patients with AIH by continent. Incidence rate reported per 1000 person-years. (C) Forest plot of incidence of HCC in patients with AIH by study population. Incidence rate reported per 1000 person-years. Clinical Gastroenterology and Hepatology 2017 15, 1207-1217.e4DOI: (10.1016/j.cgh.2017.02.006) Copyright © 2017 AGA Institute Terms and Conditions

Figure 5 Funnel plot (A) and Egger publication bias plot (B). InIR, natural log of incidence rate. Clinical Gastroenterology and Hepatology 2017 15, 1207-1217.e4DOI: (10.1016/j.cgh.2017.02.006) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 1 Sensitivity analysis. Forest plot of incidence of HCC in patients with AIH after excluding abstracts and low-quality studies. Clinical Gastroenterology and Hepatology 2017 15, 1207-1217.e4DOI: (10.1016/j.cgh.2017.02.006) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 2 Sensitivity analysis. Incidence of HCC in patients with AIH after excluding studies with zero HCC cases. Clinical Gastroenterology and Hepatology 2017 15, 1207-1217.e4DOI: (10.1016/j.cgh.2017.02.006) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 3 Sensitivity analysis. Forest plot of incidence of HCC in patients with AIH by study design. Incidence rate reported per 1000 person-years. Clinical Gastroenterology and Hepatology 2017 15, 1207-1217.e4DOI: (10.1016/j.cgh.2017.02.006) Copyright © 2017 AGA Institute Terms and Conditions