Ascending aortopathy with bicuspid aortic valve: More, but not enough, evidence for the hemodynamic theory William M. DeCampli, MD, PhD The Journal.

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Presentation transcript:

Ascending aortopathy with bicuspid aortic valve: More, but not enough, evidence for the hemodynamic theory William M. DeCampli, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 153, Issue 1, Pages 6-7 (January 2017) DOI: 10.1016/j.jtcvs.2016.10.033 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 The research approach to BAVaortopathy: past and future. Up to a few years ago, research on BAVaortopathy interpreted clinical aspects (eg, rate of progression, relation with severity of valve dysfunction, risk of dissection) with the aim of drawing inferences on the pathogenesis, that is, alternatively supporting the hemodynamic or the genetic theory. Inconclusive results and increasing awareness of the phenotypic heterogeneity have led to an inversely oriented approach: the contribution of either pathogenetic factor is investigated to identify the respective potential prognostic value in the clinical setting. AVR, Aortic valve replacement; BAV, bicuspid aortic valve. Reprinted with permission.11 The Journal of Thoracic and Cardiovascular Surgery 2017 153, 6-7DOI: (10.1016/j.jtcvs.2016.10.033) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Research approach to bicuspid aortic valve. Reprinted with permission.11 The Journal of Thoracic and Cardiovascular Surgery 2017 153, 6-7DOI: (10.1016/j.jtcvs.2016.10.033) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions