Shawn R. Hitchcock, Department of Chemistry, Illinois State University

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Presentation transcript:

b-Hydroxysalicylhydrazones: Chiral, Non-Racemic Tridentate Catalysts for Asymmetric Synthesis Shawn R. Hitchcock, Department of Chemistry, Illinois State University Our research has been primarily focused on using the Ephedra alkaloids as chiral scaffolds for the creation of chiral ligands for a organozinc reactions and the Tsuji-Trost asymmetric allylic alkylation reaction. The b-hydroxysalicylhydrazones experienced limited success in the asymmetric alkylation of aldehydes and imines, but this work inspired to development of highly effective ligands for the Tsuji-Trost reactions. The best ligand developed is capable of producing enantioselectivities as high as 99% ee. Ms. Olivia Onwodi presenting research on the synthesis of a calcimimetic agent (2010).