Effect of preoperative fever-range whole-body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery† I Sulyok, E Fleischmann,

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Presentation transcript:

Effect of preoperative fever-range whole-body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery† I Sulyok, E Fleischmann, A Stift, G Roth, D Lebherz-Eichinger, D Kasper, A Spittler, O Kimberger British Journal of Anaesthesia Volume 109, Issue 5, Pages 754-761 (November 2012) DOI: 10.1093/bja/aes248 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Heckel HT-3000 whole-body hyperthermia device. The four water-filtered infrared emitters and the tent-like structure enclosing a regular patient bed are displayed. British Journal of Anaesthesia 2012 109, 754-761DOI: (10.1093/bja/aes248) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 Mean relative levels of HSP60 in the control (blue) and WBH subjects (green) before WBH/sedation, after WBH/sedation, postoperative, 24, 48 h, and 5 days after surgery (mean, error bar: sd); difference between the groups for AUC: P=0.04, anova: *P=0.04; #P<0.05 for Fisher’s LSD. British Journal of Anaesthesia 2012 109, 754-761DOI: (10.1093/bja/aes248) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 Mean relative levels of HSP70 in the control (blue) and WBH subjects (green) before WBH/sedation, after WBH/sedation, postoperative, 24, 48 h, and 5 days after surgery (mean, error bar: sd); difference between the groups for AUC: P=0.42, anova: P=0.44. British Journal of Anaesthesia 2012 109, 754-761DOI: (10.1093/bja/aes248) Copyright © 2012 The Author(s) Terms and Conditions

Fig 4 Mean relative levels of HSP90 in the control (blue) and WBH subjects (green) before WBH/sedation, after WBH/sedation, postoperative, 24, 48 h, and 5 days after surgery (mean, error bar: sd), difference between the groups for AUC: P=0.04, anova: *P=0.03; #P<0.05 for Fisher’s LSD. British Journal of Anaesthesia 2012 109, 754-761DOI: (10.1093/bja/aes248) Copyright © 2012 The Author(s) Terms and Conditions

Fig 5 Mean relative levels of TNF-α in control (blue) and WBH subjects (green) before WBH/sedation, after WBH/sedation, after operation, 24, 48 h, and 5 days after surgery (mean, error bar: sd); difference between the groups AUC: P=0.04, anova: *P=0.04; #P<0.05 for Fisher’s LSD. British Journal of Anaesthesia 2012 109, 754-761DOI: (10.1093/bja/aes248) Copyright © 2012 The Author(s) Terms and Conditions

Fig 6 Mean relative levels of PCT in control (blue) and WBH subjects (green) before WBH/sedation, after WBH/sedation, after operation, 24, 48 h, and 5 days after surgery (mean, error bar: sd); difference between groups for AUC: P=0.02, anova: *P=0.03; #P<0.05 for Fisher’s LSD. British Journal of Anaesthesia 2012 109, 754-761DOI: (10.1093/bja/aes248) Copyright © 2012 The Author(s) Terms and Conditions