Calibration of Quality-Adjusted Life Years for Oncology Clinical Trials Jeff A. Sloan, PhD, Daniel J. Sargent, PhD, Paul J. Novotny, MS, Paul A. Decker,

Slides:

Advertisements

Similar presentations

Factors Associated With the Provision of Hospice Care for Children Lisa C. Lindley, PhD, RN, Barbara A. Mark, PhD, RN, FAAN, Shoou-Yih Daniel Lee, PhD,

Advertisements

Treatment of postherpetic neuralgia: a review of therapeutic options Charles E. Argoff, MD, Nathaniel Katz, MD, Miroslav Backonja, MD Journal of Pain and.

Validation of the Wisconsin Brief Pain Questionnaire in a Multilingual South African Population Noko Mphahlele, MSc, Duncan Mitchell, PhD, Peter Kamerman,

Spinal Cord and Peripheral Nerve Stimulation Techniques for Neuropathic Pain Oscar A. de Leon-Casasola, MD Journal of Pain and Symptom Management Volume.

Palliative Medicine Fellowship: A Study of Resident Choices

Oropharyngeal Mucositis Pain Treatment with Transdermal Buprenorphine in Patients After Allogeneic Stem Cell Transplantation Samuel Vokurka, MD, PhD

Factors to Inform Clinicians About the End of Life in Severe Chronic Obstructive Pulmonary Disease Roberto Benzo, MD, MS, Wendy Siemion, MD, Paul Novotny,

Chronic Pain Management in Older Adults: Special Considerations

The Complementary Nature of Patient-Reported Outcomes and Adverse Event Reporting in Cooperative Group Oncology Clinical Trials: A Pooled Analysis (NCCTG.

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Vincenzo Bonicalzi, MD Journal of Pain and Symptom Management

Wen Jing Chung, MD, MS, Gregory H. Pharo, DO

The Public Health Strategy for Palliative Care

Palliative Care in Norway: A National Public Health Model

Chronic Pain Management in Older Adults: Special Considerations

Opioids for Cancer Breakthrough Pain: A Pilot Study Reporting Patient Assessment of Time to Meaningful Pain Relief Giovambattista Zeppetella, FRCP Journal.

The Value of a Symptom Cluster of Fatigue, Dyspnea, and Cough in Predicting Clinical Outcomes in Lung Cancer Survivors Andrea L. Cheville, MD, MSCE,

Long-Term Opioid Therapy for Chronic Noncancer Pain: A Systematic Review and Meta-Analysis of Efficacy and Safety Meredith Noble, MS, Stephen J. Tregear,

Why Now? Timing and Circumstances of Hastened Deaths

Psychostimulants for the Management of Cancer-Related Fatigue: A Systematic Review and Meta-Analysis Ollie Minton, MSc, Alison Richardson, PhD, Michael.

Patricia Ann Repar, DMA, Steve Reid, MD, PhD

Hospice and Palliative Care Development in Africa: A Multi-Method Review of Services and Experiences David Clark, PhD, Michael Wright, PhD, Jennifer.

Relationship of Problem-Focused Coping Strategies to Changes in Quality of Life Following Treatment for Early Stage Breast Cancer Sean Ransom, MA, Paul.

What Palliative Care-Related Problems Do Patients Experience at HIV Diagnosis? A Systematic Review of the Evidence Victoria M. Simms, MSc, Irene J. Higginson,

Oropharyngeal Mucositis Pain Treatment with Transdermal Buprenorphine in Patients After Allogeneic Stem Cell Transplantation Samuel Vokurka, MD, PhD

Geographic Variation in Hospice Use in the United States in 2002

The Effect of Pain Question Phrasing on Older Adult Pain Information

Double-Blind, Placebo-Controlled Trial of Lamotrigine in Combination with Other Medications for Neuropathic Pain Marianne Silver, MS, David Blum, MD,

How to Measure the International Development of Palliative Care

Isaac M. Bromberg, MD Journal of Pain and Symptom Management

African American Bereaved Family Members' Perceptions of the Quality of Hospice Care: Lessened Disparities, But Opportunities to Improve Remain Ramona.

A Comparison of Quality-of-Life Domains and Clinical Factors in Ovarian Cancer Patients: A Gynecologic Oncology Group Study Vivian E. von Gruenigen,

Factors to Inform Clinicians About the End of Life in Severe Chronic Obstructive Pulmonary Disease Roberto Benzo, MD, MS, Wendy Siemion, MD, Paul Novotny,

What Can We Learn About the Spiritual Needs of Palliative Care Patients From the Research Literature? Mark Cobb, MA, Christopher Dowrick, MD, FRCGP,

Parent Perceptions of Child Vulnerability Are Associated With Functioning and Health Care Use in Children With Chronic Pain Mark Connelly, PhD, Kelly.

David Clark, PhD, Michael Wright, PhD

Redefining Appropriate Treatment Expectations

Amy Z. Boelk, PhD, MSSW, Betty J. Kramer, PhD, MSSW

Palliative care management services in a Medicare Social HMO

Jodi L. Hannan, MD, Steven M. Radwany, MD, Terry Albanese, PhD

Charles S. Cleeland, PhD, Jeff A. Sloan, PhD

Barrie R. Cassileth, PhD, Andrew J. Vickers, PhD

Robert L. Jayes, MD, Robert M. Arnold, MD, Erik K. Fromme, MD

Susan C. Miller, PhD, Dan K. Kiely, MPH, MA, Joan M

Do Interference-Based Cut-Points Differentiate Mild, Moderate, and Severe Levels of 16 Cancer-Related Symptoms Over Time? Sangchoon Jeon, MS, Charles.

Evaluation of the FICA Tool for Spiritual Assessment

U.S. Hospice Benefits Journal of Pain and Symptom Management

Is the B12/CRP Index More Accurate Than You at Predicting Life Expectancy in Advanced Cancer Patients? Filipa Tavares, MD Journal of Pain and Symptom.

Álvaro Sanz Rubiales, MD, PhD, Virginia de la Cruz, MD

Development and Reliability Testing of the Victoria Bowel Performance Scale (BPS) G. Michael Downing, MD, Craig Kuziemsky, PhD, Mary Lesperance, PhD,

Association Between Symptom Distress and Survival in Outpatients Seen in a Palliative Care Cancer Center J. Lynn Palmer, PhD, Michael J. Fisch, MD, MPH

A New Approach to Eliciting Patients' Preferences for Palliative Day Care: The Choice Experiment Method Hannah-Rose Douglas, PhD, Charles E. Normand,

Tomoyuki Kawada, MD Journal of Pain and Symptom Management

Predictors of Quality of Life in Oncology Outpatients with Pain from Bone Metastasis Tone Rustøen, RN, PhD, Torbjørn Moum, PhD, Geraldine Padilla, PhD,

Perceived Success in Addressing End-of-Life Care Needs of Low-Income Elders and Their Families: What Has Family Conflict Got to Do With It? Betty J.

Psychometric update of the Functional Interference Estimate: a brief measure of pain functional interference Robert J. Ferguson, PhD, Janette Seville,

Reporting of Funding Sources and Conflict of Interest in the Supportive and Palliative Oncology Literature David Hui, MD, MSc, FRCPC, Akhila Reddy, MD,

The Bow Tie Model of 21st Century Palliative Care

Coping Strategies in the Presence of One's Own Impending Death from Cancer Lisa Sand, MSW, PhD (C), Mariann Olsson, MSW, PhD, Peter Strang, MD, PhD Journal.

Amy P. Abernethy, MD Journal of Pain and Symptom Management

Optimizing Decision Making and Resource Allocation in Palliative Care

A Comparison of Quality-of-Life Domains and Clinical Factors in Ovarian Cancer Patients: A Gynecologic Oncology Group Study Vivian E. von Gruenigen,

Long-Term Opioid Therapy for Chronic Noncancer Pain: A Systematic Review and Meta-Analysis of Efficacy and Safety Meredith Noble, MS, Stephen J. Tregear,

Helping Patients with Advanced Cancer Live with Concerns About Eating: A Challenge for Palliative Care Professionals Jane Hopkinson, PhD, RGN, Jessica.

Advance Directives in Japanese Nursing Homes

Cancer Symptom Clusters: A Validation Study

Associations Between Physical Activity and Quality of Life in Cancer Patients Receiving Palliative Care: A Pilot Survey Sonya S. Lowe, MD, MSc, Sharon.

Randomized Double-Blind Trial of Sublingual Atropine vs

Physical Activity Behaviors in Individuals with Multiple Sclerosis: Roles of Overall and Specific Symptoms, and Self-Efficacy Erin M. Snook, MS, Robert.

Presentation transcript:

Calibration of Quality-Adjusted Life Years for Oncology Clinical Trials Jeff A. Sloan, PhD, Daniel J. Sargent, PhD, Paul J. Novotny, MS, Paul A. Decker, MS, Randolph S. Marks, MD, Heidi Nelson, MD Journal of Pain and Symptom Management Volume 47, Issue 6, Pages 1091-1099.e3 (June 2014) DOI: 10.1016/j.jpainsymman.2013.07.016 Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Power for n=300 per group, HR=1.0, 10% toxicity in the reference arm, and varying the toxicity rate in the other arm. Journal of Pain and Symptom Management 2014 47, 1091-1099.e3DOI: (10.1016/j.jpainsymman.2013.07.016) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Power for double toxicity rate in one arm and utility of 0.3 for varying sample sizes and hazard rates. Journal of Pain and Symptom Management 2014 47, 1091-1099.e3DOI: (10.1016/j.jpainsymman.2013.07.016) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Power for n=300 per group, HR=1.0, and Ut=0.3 for varying toxicity rates in the reference and other arm. Journal of Pain and Symptom Management 2014 47, 1091-1099.e3DOI: (10.1016/j.jpainsymman.2013.07.016) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 4 Power for n=300 per group, HR=1.0, and Ut=0.3 for varying toxicity rates in the reference and other arm. Journal of Pain and Symptom Management 2014 47, 1091-1099.e3DOI: (10.1016/j.jpainsymman.2013.07.016) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

Journal of Pain and Symptom Management 2014 47, 1091-1099. e3DOI: (10 Journal of Pain and Symptom Management 2014 47, 1091-1099.e3DOI: (10.1016/j.jpainsymman.2013.07.016) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

Journal of Pain and Symptom Management 2014 47, 1091-1099. e3DOI: (10 Journal of Pain and Symptom Management 2014 47, 1091-1099.e3DOI: (10.1016/j.jpainsymman.2013.07.016) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions

Journal of Pain and Symptom Management 2014 47, 1091-1099. e3DOI: (10 Journal of Pain and Symptom Management 2014 47, 1091-1099.e3DOI: (10.1016/j.jpainsymman.2013.07.016) Copyright © 2014 U.S. Cancer Pain Relief Committee Terms and Conditions