Association of Serum Levels of Adipokines and Insulin With Risk of Barrett's Esophagus: A Systematic Review and Meta-Analysis  Apoorva Krishna Chandar,

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Association of Serum Levels of Adipokines and Insulin With Risk of Barrett's Esophagus: A Systematic Review and Meta-Analysis  Apoorva Krishna Chandar, Swapna Devanna, Chang Lu, Siddharth Singh, Katarina Greer, Amitabh Chak, Prasad G. Iyer  Clinical Gastroenterology and Hepatology  Volume 13, Issue 13, Pages 2241-2255.e4 (December 2015) DOI: 10.1016/j.cgh.2015.06.041 Copyright © 2015 Terms and Conditions

Figure 1 Forest plot showing association between total serum adiponectin and BE risk in comparison with population control subjects (top) and with GERD control subjects (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions

Figure 2 Forest plot showing association between serum leptin and BE risk in comparison with population control subjects (top) and with GERD control subjects (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions

Figure 3 Forest plot showing association between serum insulin and BE risk in comparison with population control subjects (top) and with GERD control subjects (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions

Figure 4 Forest plot showing association between insulin resistance (HOMA-IR) and BE risk in comparison with population control subjects (top) and with GERD control subjects (bottom). SE, standard error. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions

Supplementary Figure 1 Flow diagram summarizing study identification and selection. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions

Supplementary Figure 2 Forest plot showing association between HMW adiponectin and BE risk in comparison with GERD control subjects. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions

Supplementary Figure 3 Forest plot showing association between total serum adiponectin and BE risk when compared with population control subjects in males (top) and females (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions

Supplementary Figure 4 Forest plot showing association between total serum adiponectin and BE risk in comparison with GERD control subjects in males (top) and females (bottom). SE, standard error. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions

Supplementary Figure 5 Forest plot showing association between serum leptin and BE risk in comparison with population control subjects in males (top) and females (bottom). NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions

Supplementary Figure 6 Forest plot showing sensitivity analysis (Garcia 2014 excluded) for the association between serum leptin and BE risk when compared with population control subjects. NSAIDs, nonsteroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SE, standard error. Clinical Gastroenterology and Hepatology 2015 13, 2241-2255.e4DOI: (10.1016/j.cgh.2015.06.041) Copyright © 2015 Terms and Conditions