Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis Sakari Reitamo, MDa,

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Presentation transcript:

Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone acetate ointment in children with atopic dermatitis Sakari Reitamo, MDa, Edwin J.M. Van Leent, MDb, Vincent Ho, MDc, John Harper, FRCPd, Thomas Ruzicka, MDe, Kirsti Kalimo, MDf, Frédéric Cambazard, MDg, Malcolm Rustin, MDh, Alain Taïeb, MDi, David Gratton, MDj, Daniel Sauder, MDk, Graham Sharpe, FRCPl, Catherine Smith, FRCPm, Michael Jünger, MDn, Yves de Prost, MDo Journal of Allergy and Clinical Immunology Volume 109, Issue 3, Pages 539-546 (March 2002) DOI: 10.1067/mai.2002.121831 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Median percentage decreases from baseline (and upper and lower quartiles) in mEASI and affected BSA. The mEASI considers the affected BSA and the severity of erythema, edema, excoriations, lichenification, and itching. At the end of treatment, the greater improvement with either tacrolimus concentration compared with 1% hydrocortisone acetate was significant (P ≤ .001), as was the greater improvement with 0.1% compared with 0.03% tacrolimus (P < .05). Journal of Allergy and Clinical Immunology 2002 109, 539-546DOI: (10.1067/mai.2002.121831) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Physician's global evaluation of clinical response at the end of treatment and the end of follow-up. The population for analysis at the end of treatment was an intent-to-treat population, with 185, 187, and 184 patients included in the 1% hydrocortisone acetate group, the 0.03% tacrolimus group, and the 0.1% tacrolimus groups, respectively. The difference in the proportion of patients who had clearance or excellent improvement was significant between tacrolimus and hydrocortisone acetate (P = .001) but not between 0.03% and 0.1% tacrolimus (P = .055). The population for analysis of follow-up included only patients who had moderate improvement at the end of treatment and continued prohibited therapy restrictions, with 88, 134, and 144 patients, respectively. Journal of Allergy and Clinical Immunology 2002 109, 539-546DOI: (10.1067/mai.2002.121831) Copyright © 2002 Mosby, Inc. Terms and Conditions