A Drug-Drug Interaction Crystallizes a New Entry Point into the UPR Kevan M. Shokat  Molecular Cell  Volume 38, Issue 2, Pages 161-163 (April 2010) DOI: 10.1016/j.molcel.2010.04.011 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 X-Ray Crystallographic Structures of Several Examples of Drug-Drug Dimers Found in Complex with a Protein IRE1 or Duplex DNA (A–C) Quercetin dimer at the IRE1 dimer interface (A), 2:1 distamycin:DNA complex (PDB ID: 378D) (Mitra et al., 1999) (B), and 2:1 chromomycin:DNA complex (PDB ID: 1VAQ) (Hou et al., 2004) (C). Protein in (A) and DNA in (B) and (C) are shown in ribbon or surface representation. In each panel, the two identical ligands are colored differently, with the carbon atoms in one molecule in yellow and in the other, purple. In (A) and (B), the noncarbon atoms oxygen and nitrogen are shown in red and blue, respectively. In (C), all atoms of each ligand are colored purple or yellow, with the exception of Mg2+, which is shown as a red sphere. Molecular Cell 2010 38, 161-163DOI: (10.1016/j.molcel.2010.04.011) Copyright © 2010 Elsevier Inc. Terms and Conditions