Genome Sequences from Extinct Relatives

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Genome Sequences from Extinct Relatives Andrew G. Clark  Cell  Volume 134, Issue 3, Pages 388-389 (August 2008) DOI: 10.1016/j.cell.2008.07.026 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 A Hominid Family Tree A population splitting tree is depicted as the large inverted Y structure (beige), showing that humans and Neanderthals derived from a common population at some point in the past. Within this are the lineages of nuclear genes (blue) and mitochondrial DNA (mtDNA) sequences (red). The indicated dates are as follows: 38 KYA (thousand years ago)—the time that the Neanderthal specimen lived; 171 KYA—the inferred “time to most recent common ancestry” (TMRCA) for modern human mtDNA sequences (Garrigan and Hammer, 2006); 370 KYA—the time of the ancestral human-Neanderthal population split (Noonan et al., 2006); 660 KYA—the TMRCA for human and Neanderthal mtDNA (Green et al., 2008); 706 KYA—the TMRCA for human and Neanderthal nuclear sequences (Noonan et al., 2006). Not shown are the times of the oldest paleontological evidence of Neanderthals (400–500 KYA) or the TMRCA for modern human nuclear genes, many of which lie in the range of 1 to 4 million years ago (MYA) (Garrigan and Hammer, 2006). Cell 2008 134, 388-389DOI: (10.1016/j.cell.2008.07.026) Copyright © 2008 Elsevier Inc. Terms and Conditions