A large familial pathogenic Plakophilin-2 gene (PKP2) deletion manifesting with sudden cardiac death and lone atrial fibrillation: Evidence for alternating.

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Presentation transcript:

A large familial pathogenic Plakophilin-2 gene (PKP2) deletion manifesting with sudden cardiac death and lone atrial fibrillation: Evidence for alternating atrial and ventricular phenotypes Saad Alhassani, MD, Bishoy Deif, MD, Susan Conacher, MSc, Kristopher S. Cunningham, MD, PhD, Jason D. Roberts, MD, MAS HeartRhythm Case Reports Volume 4, Issue 10, Pages 486-489 (October 2018) DOI: 10.1016/j.hrcr.2018.07.009 Copyright © 2018 Heart Rhythm Society Terms and Conditions

Figure 1 Twelve-lead surface electrocardiograms of family members possessing the large PKP2 deletion. A: Deceased proband. B, C: Proband’s brothers with atrial fibrillation, aged 26 (B) and 24 (C). D: Proband’s mother. HeartRhythm Case Reports 2018 4, 486-489DOI: (10.1016/j.hrcr.2018.07.009) Copyright © 2018 Heart Rhythm Society Terms and Conditions

Figure 2 Kindred structure. Black, navy blue, and red fill denote sudden cardiac death, atrial fibrillation, and nonsustained atrial arrhythmias, respectively. The family member inaccessible for evaluation is shaded in gray. Genotype is denoted as +/- and age at evaluation or at time of death is provided below. HeartRhythm Case Reports 2018 4, 486-489DOI: (10.1016/j.hrcr.2018.07.009) Copyright © 2018 Heart Rhythm Society Terms and Conditions

Figure 3 Wild-type PKP2 gene (14 exons) and the large familial genomic deletion resulting in a truncated gene limited to exons 1–3. GRCh37 genomic coordinates. HeartRhythm Case Reports 2018 4, 486-489DOI: (10.1016/j.hrcr.2018.07.009) Copyright © 2018 Heart Rhythm Society Terms and Conditions