Functional and Mechanistic Insights into the Pathogenesis of P63-Associated Disorders  Maria Rosaria Mollo, Luisa Cirillo, Claudia Russo, Dario Antonini, Caterina Missero  Journal of Investigative Dermatology Symposium Proceedings  Volume 19, Issue 2, Pages S98-S100 (December 2018) DOI: 10.1016/j.jisp.2018.10.004 Copyright © 2018 The Authors Terms and Conditions

Figure 1 Disruption of the epidermal barrier in atopic dermatitis and in Netherton syndrome induces massive production of TSLP protein by keratinocytes that contribute to induce a local and systemic inflammatory response (left panel). In AEC syndrome, skin erosions caused by acantholysis and cytolysis occurring primarily in the basal layer lead to similar overproduction of TSLP, which is released in the bloodstream (right panel). AEC, ankyloblepharon-ectodermal defects-cleft lip/palate. Journal of Investigative Dermatology Symposium Proceedings 2018 19, S98-S100DOI: (10.1016/j.jisp.2018.10.004) Copyright © 2018 The Authors Terms and Conditions