Successful treatment of hydroxyurea-associated panniculitis and vasculitis with low- dose methotrexate Sarah Mattessich, BS, Katalin Ferenczi, MD, Jun.

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Successful treatment of hydroxyurea-associated panniculitis and vasculitis with low- dose methotrexate Sarah Mattessich, BS, Katalin Ferenczi, MD, Jun Lu, MD JAAD Case Reports Volume 3, Issue 5, Pages 422-424 (September 2017) DOI: 10.1016/j.jdcr.2017.06.009 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Clinical presentations of multiple erythematous indurated plaques and subcutaneous nodules on the lower back (A), leg (B), and dorsal foot (C). JAAD Case Reports 2017 3, 422-424DOI: (10.1016/j.jdcr.2017.06.009) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histologic examination. A, Deep dermal and subcutaneous infiltrate. B, Septal thickening and inflammation with lobular spilling of the infiltrate. C, Vessel wall infiltration by inflammatory cells with luminal obliteration and adjacent eosinophil-rich infiltrate. (A, Hematoxylin-eosin stain; original magnifications: A, ×10; B, ×20; C, ×40.) JAAD Case Reports 2017 3, 422-424DOI: (10.1016/j.jdcr.2017.06.009) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Complete resolution of vasculitis and panniculitis after low-dose methotrexate treatment. JAAD Case Reports 2017 3, 422-424DOI: (10.1016/j.jdcr.2017.06.009) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions