Uremic pruritus Kidney International

Slides:

Advertisements

Similar presentations

Acute interstitial nephritis

Advertisements

Volume 70, Issue 3, Pages (August 2006)

Diffuse vascular calcification in a dialysis patient

Neurophysiological, Neuroimmunological, and Neuroendocrine Basis of Pruritus Martin Steinhoff, John Bienenstock, Martin Schmelz, Marcus Maurer, Ed Wei,

Therapeutic pipeline for atopic dermatitis: End of the drought?

Acute interstitial nephritis

Volume 61, Issue 2, (February 2002)

Volume 72, Issue 1, Pages (July 2007)

IL-17A Has Some Nerve! Immunity

Glomerular disease related to anti-VEGF therapy

C.-W. Tsai, V.-C. Wu, W.-C. Lin, J.-W. Huang, M.-S. Wu

Volume 4, Issue 2, Pages (March 2018)

M. Fukagawa, S. Nakanishi, J.J. Kazama Kidney International

Peritubular capillaritis in the renal allograft takes center stage

Volume 58, Issue 1, Pages (July 2000)

Volume 71, Issue 8, Pages (April 2007)

The Case | Hypertension and neuropathy after travel

Volume 70, Pages S21-S25 (December 2006)

Recapitulating Atopic Dermatitis in Three Dimensions: Cross Talk between Keratinocytes and Nerve Fibers Carlo Pincelli, Martin Steinhoff Journal of.

Kidney International in 2007: Celebrating new features

Volume 74, Issue 3, Pages (August 2008)

Volume 70, Issue 11, Pages (December 2006)

G.S. Markowitz, C. Gelber, V.D. D'agati Kidney International

Severe exfoliative skin rash with icodextrin

Massive bilateral nephromegaly in an infant

Volume 71, Issue 11, Pages (June 2007)

Volume 86, Issue 2, Pages (August 2014)

Renal vascular sclerosis is associated with inherited thrombophilias

The Case ∣ Renal failure, sepsis, and bilateral kidney tumors

Mohamad Zaidan, Julien Adam, Pascale Cervera-Pierot, Dominique Joly

Volume 71, Issue 6, Pages (March 2007)

Volume 70, Issue 12, Pages (December 2006)

Analgesic nephropathy

Blood pressure targets in hemodialysis patients

Volume 70, Issue 8, Pages (October 2006)

Fructose intake as a risk factor for kidney stone disease

Grace A. Hile, BS, Lori Lowe, MD, J. Michelle Kahlenberg, MD, PhD

An unusual cause of acute renal failure

The third World Kidney Day: Looking back and thinking forward

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Crossed fused ectopia of the kidneys

Volume 71, Issue 4, Pages (February 2007)

Antiglomerular basement membrane disease with normal renal function

Fibroblast growth factor 23: the making of a hormone

Volume 69, Issue 9, Pages (May 2006)

Acute onset of hematuria and proteinuria associated with multiorgan involvement of the heart, liver, pancreas, kidneys, and skin in a patient with Henoch–Schönlein.

Destructive spondyloarthropathy

H. Raffi, J.M. Bates, Z. Laszik, S. Kumar Kidney International

W.-Y. Li, V.-C. Wu, W.-C. Lin, Y.-M. Chen

Nervous elements influencing intestinal inflammation and rotavirus diarrhea may lead to new treatments Dan Gordon Gastroenterology Volume 118, Issue.

Endothelial cell activation

Organ transplantation goes to the movies

Volume 72, Issue 2, Pages (July 2007)

Diagnosing Alport syndrome using electron microscopy of the skin

D. Fuster, A. Monegal, J.-V. Torregrosa Kidney International

Post-renal acute renal failure

Is it the low-protein diet or simply the salt restriction?

Urinalysis in Western culture: A brief history

Volume 70, Issue 3, Pages (August 2006)

A 39-year-old pregnant woman with polyuria and hypomagnesemia

Volume 71, Issue 9, Pages (May 2007)

Advisory about gadolinium calls for caution in the treatment of uremic patients with lanthanum carbonate S. Aime, C. Canavese, P. Stratta Kidney International

Volume 70, Issue 5, Pages (September 2006)

Volume 75, Issue 7, Pages (April 2009)

T cells and T-cell receptors in acute renal failure

The International Pediatric Peritonitis Registry: Starting to walk

M.B. Stokes, B. Aronoff, D. Siegel, V.D. D'Agati Kidney International

Volume 72, Issue 12, (December 2007)

Grace A. Hile, BS, Lori Lowe, MD, J. Michelle Kahlenberg, MD, PhD

Presentation transcript:

Uremic pruritus Kidney International S.R. Keithi-Reddy, T.V. Patel, A.W. Armstrong, A.K. Singh Kidney International Volume 72, Issue 3, Pages 373-377 (August 2007) DOI: 10.1038/sj.ki.5002197 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Examination of skin. (a) Intense skin rash on the lower extremity. (b) Intense skin rash on the back. Kidney International 2007 72, 373-377DOI: (10.1038/sj.ki.5002197) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 2 Skin biospy findings. (a) Superficial perivascular lymphocytic infiltrate with eosinophils, dermal hemorrhage, and psoriasiform hyperplasia. Periodic acid-Schiff digested stain negative for fungal elements (original magnification × 10). (b) Superficial perivascular, predominantly lymphocytic infiltrate with eosinophils (original magnification × 40). Kidney International 2007 72, 373-377DOI: (10.1038/sj.ki.5002197) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 3 Working model for pathogenesis of uremic pruritus. (1) Several substances have been proposed to produce pruritogenic environment. (2) Histamine released from mast cells, in response to pruritogenic substances, stimulates C-terminal nerve endings. (3) A cascade of signals from nerve endings activate specific areas in the central nervous system resulting in perception of itch. (4) By a direct axon reflex mechanism, sensory nerve endings release neuropeptides. (5) Locally released neuropeptides aggravate the itch response by stimulating accumulation of inflammatory cells and release of pruritic mediators. Kidney International 2007 72, 373-377DOI: (10.1038/sj.ki.5002197) Copyright © 2007 International Society of Nephrology Terms and Conditions