Evidence for Linkage and Association with Reading Disability, on 6p21

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Evidence for Linkage and Association with Reading Disability, on 6p21 D.E. Kaplan, J. Gayán, J. Ahn, T.-W. Won, D. Pauls, R.K. Olson, J.C. DeFries, F. Wood, B.F. Pennington, G.P. Page, S.D. Smith, J.R. Gruen The American Journal of Human Genetics Volume 70, Issue 5, Pages 1287-1298 (May 2002) DOI: 10.1086/340449 Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 1 Location and distribution of the 29 STR markers used for linkage and association studies as described elsewhere (J. Ahn, T.-W. Won, D. E. Kaplan, E. R. Londin, P. Kuzmic, J. Gelernter, and J. R. Gruen, unpublished data). The American Journal of Human Genetics 2002 70, 1287-1298DOI: (10.1086/340449) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 2 T scores across the chromosomal region for the most significant test of linkage for each phenotype. Chromosomal location (in cM) is expressed proximally from JA01. The American Journal of Human Genetics 2002 70, 1287-1298DOI: (10.1086/340449) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 3 Significant results from QTDT output for the orthogonal model of association with environmental, polygenic, and additive major locus variance-components modeling. All results with P <.02 are graphed corresponding to table 3. Significance levels are shown on the basis of the nominal P values from the QTDT output. The American Journal of Human Genetics 2002 70, 1287-1298DOI: (10.1086/340449) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 4 Graphical output from GOLD (Abecasis and Cookson 2000), showing intermarker linkage disequilibrium (D′) independent of reading phenotype data. The American Journal of Human Genetics 2002 70, 1287-1298DOI: (10.1086/340449) Copyright © 2002 The American Society of Human Genetics Terms and Conditions