Matthias H. Tschöp, Michael Stumvoll, Michael Ristow Cell Metabolism

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Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis Matthias H. Tschöp, Michael Stumvoll, Michael Ristow Cell Metabolism Volume 23, Issue 6, Pages 959-960 (June 2016) DOI: 10.1016/j.cmet.2016.05.017 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Mitochondrial ROS and Its Upstream Modifiers in the Control of Cancer and Metastasis Antidiabetic interventions like physical exercise and metformin induce formation of mitochondrial reactive oxygen species (mtROS), while antioxidants like alpha-lipoic acid quench the formation of such free radicals. Likewise, and as elaborated on in the current study (Wang et al., 2016), antidiabetic DPP4-Is like Sax and Sit somehow activate the transcription factor NRF2, which in turn induces the endogenous antioxidant defense of the cell, culminating in increased metastatic capacity. Cell Metabolism 2016 23, 959-960DOI: (10.1016/j.cmet.2016.05.017) Copyright © 2016 Elsevier Inc. Terms and Conditions