Association Between Pharmacokinetics of Adalimumab and Mucosal Healing in Patients With Inflammatory Bowel Diseases Xavier Roblin, Hubert Marotte, Melanie.

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Presentation transcript:

Association Between Pharmacokinetics of Adalimumab and Mucosal Healing in Patients With Inflammatory Bowel Diseases Xavier Roblin, Hubert Marotte, Melanie Rinaudo, Emilie Del Tedesco, Amelie Moreau, Jean Marc Phelip, Christian Genin, Laurent Peyrin–Biroulet, Stephane Paul Clinical Gastroenterology and Hepatology Volume 12, Issue 1, Pages 80-84.e2 (January 2014) DOI: 10.1016/j.cgh.2013.07.010 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 (A) Comparison of ADA trough levels between IBD patients with MH and those without MH (P < .005). (B) Quartiles of ADA trough levels for the obtention of MH (P = .001). Clinical Gastroenterology and Hepatology 2014 12, 80-84.e2DOI: (10.1016/j.cgh.2013.07.010) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Comparison of ADA trough levels between IBD patients with MH and those without MH in CD and UC (P = .04). Clinical Gastroenterology and Hepatology 2014 12, 80-84.e2DOI: (10.1016/j.cgh.2013.07.010) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 ROC curves for trough levels of ADA in IBD patients (MH vs no MH). NPV, negative predictive value; PPV, positive predictive value. Clinical Gastroenterology and Hepatology 2014 12, 80-84.e2DOI: (10.1016/j.cgh.2013.07.010) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 (A) Comparison of ADA trough levels between IBD patients in clinical remission (CR) and those with active disease (P = .012). (B) Quartiles of ADA values for the obtention of clinical remission (P = .001). Clinical Gastroenterology and Hepatology 2014 12, 80-84.e2DOI: (10.1016/j.cgh.2013.07.010) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 2 ROC curves for trough levels of ADA in IBD patients (CR vs no CR). CR, clinical remission; NPV, negative predictive value; PPV, positive predictive value. Clinical Gastroenterology and Hepatology 2014 12, 80-84.e2DOI: (10.1016/j.cgh.2013.07.010) Copyright © 2014 AGA Institute Terms and Conditions