D.J. Hunter Osteoarthritis and Cartilage

Slides:

Advertisements

Similar presentations

Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.

Advertisements

D. Pereira, B. Peleteiro, J. Araújo, J. Branco, R.A. Santos, E. Ramos

Mesenchymal stromal cells for cartilage repair in osteoarthritis

Short-term placebo response in trials of patients with symptomatic osteoarthritis: differences between hip and knee S. Reiter-Niesert, M. Boers, J. Detert

Dr L. S. Kim, N. D. , Dr L. J. Axelrod, N. D. , Dr P. Howard, M. D

The epidemiology and impact of pain in osteoarthritis

P.-S. Hsu, H.-H. Lin, C.-R. Li, W.-S. Chung

Osteoarthritis pain mechanisms: basic studies in animal models

One year effectiveness of neuromuscular exercise compared with instruction in analgesic use on knee function in patients with early knee osteoarthritis:

S. Gavard Osteoarthritis and Cartilage

Influence of flare design on symptomatic efficacy of non-steroidal anti-inflammatory drugs in osteoarthritis: a meta-analysis of randomized placebo-controlled.

Associations between pre-operative radiographic changes and outcomes after total knee joint replacement for osteoarthritis M.M. Dowsey, M. Nikpour, P.

H. A. Kim, I. Kim, Y. W. Song, D. H. Kim, J. Niu, A. Guermazi, M. D

Osteoarthritis as a disease of mechanics

No evidence for the effectiveness of a multidisciplinary group based treatment program in patients with osteoarthritis of hands on the short term; results.

Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials M. Fransen, S.

Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives Y. Henrotin Osteoarthritis and Cartilage

Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: data from the Osteoarthritis Initiative

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Transdermal buprenorphine plus oral paracetamol vs an oral codeine-paracetamol combination for osteoarthritis of hip and/or knee: a randomised trial

Efficacy and safety of intraarticular hyaluronic acid in the treatment of hip osteoarthritis: a systematic review J.C. Fernández López, M.D., Ph.D.,

Osteoarthritis pain mechanisms: basic studies in animal models

L. Menashe, K. Hirko, E. Losina, M. Kloppenburg, W. Zhang, L. Li, D. J

Current and emerging management options for Clostridium difficile infection: what is the role of fidaxomicin? O.A. Cornely Clinical Microbiology and.

Time to be positive about negative data?

Equivalence of a single dose (1200 mg) compared to a three-time a day dose (400 mg) of chondroitin 4&6 sulfate in patients with knee osteoarthritis. Results.

Summary of the OA biomarkers workshop 2009 – biochemical biomarkers: biology, validation, and clinical studies V.B. Kraus, M. Nevitt, L.J. Sandell Osteoarthritis.

J. Avouac, M.D., L. Gossec, M.D., M. Dougados, M.D.

Stem cell therapy for human cartilage defects: a systematic review

S. Sonne-Holm, M.D., Dr. Sci., S. Jacobsen, M.D.

J. Ranstam Osteoarthritis and Cartilage

Osteoarthritis year 2010 in review: non-pharmacologic therapy

Clinically important body weight gain following total hip arthroplasty: a cohort study with 5-year follow-up D.L. Riddle, J.A. Singh, W.S. Harmsen, C.D.

Ethics in musculoskeletal regenerative medicine; guidance in choosing the appropriate comparator in clinical trials T.S. de Windt, S.L. Niemansburg,

Osteoarthritis of the knee after meniscal resection: long term radiographic evaluation of disease progression P.T. Paradowski, L.S. Lohmander, M. Englund

M.Y. Chan, J.R. Center, J.A. Eisman, T.V. Nguyen

Utilization rates of hip arthroplasty in OECD countries

Scientific production and impact of national registers: the example of orthopaedic national registers P. Boyer, I. Boutron, P. Ravaud Osteoarthritis.

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis M. Blagojevic, C. Jinks, A. Jeffery, K.P.

A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open- source tool for histological grading H.E. Kloefkorn, B.Y. Jacobs,

V. B. Kraus, B. Burnett, J. Coindreau, S. Cottrell, D. Eyre, M

Imaging Biomarker Validation and Qualification Report: Sixth OARSI Workshop on Imaging in Osteoarthritis combined with Third OA Biomarkers Workshop D.J.

Structural changes in the knee during weight loss maintenance after a significant weight loss in obese patients with osteoarthritis: a report of secondary.

Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials E.M. Bartels, V.N. Folmer, H. Bliddal,

Who should have a joint replacement? A plea for more ‘phronesis’

Poor replicability of recommended exercise interventions for knee osteoarthritis: a descriptive analysis of evidence informing current guidelines and.

Hip strengthening reduces symptoms but not knee load in people with medial knee osteoarthritis and varus malalignment: a randomised controlled trial

Chondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled study J. Yue, M. Yang, S. Yi,

The hallmarks of osteoarthritis and the potential to develop personalised disease- modifying pharmacological therapeutics D.P. Tonge, M.J. Pearson, S.W.

A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee T.J. Schnitzer, J.A. Marks Osteoarthritis.

D.J. Hunter Osteoarthritis and Cartilage

A comparison of intra-articular hyaluronan injection accuracy rates between three approaches based on radiographic severity of knee osteoarthritis Y.

S.G. Muthuri, D.F. McWilliams, M. Doherty, W. Zhang

Limited effects of exercises in people with hand osteoarthritis: results from a randomized controlled trial N. Østerås, K.B. Hagen, M. Grotle, A.-L.

Preoperative progressive explosive-type resistance training is feasible and effective in patients with hip osteoarthritis scheduled for total hip arthroplasty.

C. Ratzlaff, M. Koehoorn, J. Cibere, J. Kopec

Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study L. Busija, R. Buchbinder, R.H. Osborne Osteoarthritis.

N. Frey, T. Hügle, S.S. Jick, C.R. Meier, J. Spoendlin

Osteoarthritis year 2012 in review: biology

Location-specific hip joint space width for progression of hip osteoarthritis – Data from the Osteoarthritis Initiative C. Ratzlaff, C. Van Wyngaarden,

L.A. Deveza, L. Melo, T.P. Yamato, K. Mills, V. Ravi, D.J. Hunter

Systematic review of the impact of osteoarthritis on health outcomes for comorbid disease in older people L. Parkinson, D.L. Waters, L. Franck Osteoarthritis.

D.T. Felson Osteoarthritis and Cartilage

Osteoarthritis year in review 2016: mechanics

The relationship between foot and ankle symptoms and risk of developing knee osteoarthritis: data from the osteoarthritis initiative K.L. Paterson, J.

Trapeziometacarpal subluxation predisposes to incident trapeziometacarpal osteoarthritis (OA): the Framingham study D.J. Hunter, M.B.B.S., Ph.D., Y.

M. Doherty, P. Dieppe Osteoarthritis and Cartilage

Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea I.J. Kim, D.H. Kim, J.Y.

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Presentation transcript:

The great debate: Should Osteoarthritis Research Focus on “Mice” or “Men”? D.J. Hunter Osteoarthritis and Cartilage Volume 24, Issue 1, Pages 4-8 (January 2016) DOI: 10.1016/j.joca.2015.07.029 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Reasons for trial failures of disease modifying drugs in OA. Osteoarthritis and Cartilage 2016 24, 4-8DOI: (10.1016/j.joca.2015.07.029) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Stages of waste in the production and reporting of biomedical research evidence relevant to clinicians and patient. Reprinted with permission from Chalmers I and Glasziou P. Lancet 2009; 374: 86–89, Copyright (2009), with permission from Elsevier. Osteoarthritis and Cartilage 2016 24, 4-8DOI: (10.1016/j.joca.2015.07.029) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions