Fig. 7. Genetic ablation of UCP2 compromised the protective effect of exogenous irisin on lung IR injury. Genetic ablation of UCP2 compromised the protective.

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Fig. 7. Genetic ablation of UCP2 compromised the protective effect of exogenous irisin on lung IR injury. Genetic ablation of UCP2 compromised the protective effect of exogenous irisin on lung IR injury. (A) Histopathological changes in IR-injured lung in WT or Ucp2−/− mice, with or without irisin administration (scale bars, 50 μm). (B) Histopathological assessment (lung injury score) of pulmonary tissue for each group is summarized. The staining for each group was repeated at least five times, and 15 fields of vision in each slide were chosen for histopathological assessment (*P < 0.05 versus WT mice under same conditions and #P < 0.05 versus IR group in WT mice). (C) Immunohistochemical staining shows targeting of irisin to the injured alveolar cells in WT and Ucp2−/− mice (scale bars, 50 μm). (D) Lung edema, determined by wet/dry ratio in WT and Ucp2−/− mice after IR injury (*P < 0.05 versus WT mice under same conditions and #P < 0.05 versus IR group in WT mice; n = 5). Measurement of PaO2 (E) and PaCO2 (F) in WT and Ucp2−/− mice after IR injury (*P < 0.05 versus WT mice under same conditions and #P < 0.05 versus IR group in WT mice; n = 5). Ken Chen et al., Sci Transl Med 2017;9:eaao6298 Published by AAAS