Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device Paul M Heerdt, MD, PhD, Michael Schlame, MD, Roswitha Jehle,

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Presentation transcript:

Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device Paul M Heerdt, MD, PhD, Michael Schlame, MD, Roswitha Jehle, MD, Alessandro Barbone, MD, Daniel Burkhoff, MD, PhD, Thomas J.J Blanck, MD, PhD The Annals of Thoracic Surgery Volume 73, Issue 4, Pages 1216-1221 (April 2002) DOI: 10.1016/S0003-4975(01)03621-9

Fig 1 Representative chromatogram for cardiolipin molecular species.( L4 = tetralinoleoyl-cardiolipin; L3O = trilinoleoyl-oleoyl-cardiolipin; L2O2 = dilinoleoyl-dioleoyl-cardiolipin.) The Annals of Thoracic Surgery 2002 73, 1216-1221DOI: (10.1016/S0003-4975(01)03621-9)

Fig 2 Total cardiolipin content and myocyte diameter in four nonfailing, nine failing (CHF), and 12 left ventricular assist device (LVAD)-supported hearts. ∗Difference from nonfailing. Data are presented as mean ± standard error. The Annals of Thoracic Surgery 2002 73, 1216-1221DOI: (10.1016/S0003-4975(01)03621-9)

Fig 3 Ratios of cardiolipin molecular species with all heart samples pooled or divided by underlying disease. Data are presented as mean ± standard error. (CHF = failing hearts; DCM = dilated cardiomyopathy; ICM = ischemic cardiomyopathy; LVAD = left ventricular assist device-supported hearts; L4 = tetralinoleoyl-cardiolipin; L3O = trilinoleoyl-oleoyl-cardiolipin; L2O2 = dilinoleoyl-dioleoyl-cardiolipin. ∗Difference from nonfailing; diamond = difference between CHF versus LVAD.) The Annals of Thoracic Surgery 2002 73, 1216-1221DOI: (10.1016/S0003-4975(01)03621-9)