Triggered Sequestration with DNA Nanoboxes: A New Drug Delivery Method

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Presentation transcript:

Triggered Sequestration with DNA Nanoboxes: A New Drug Delivery Method June 26, 2006 iGEM Week 3: Design Progress Tiffany Chan, Katherine Fifer, Valerie Lau, Matthew Meisel

Design Specifications Calculating coil length: The distance between stacked base pairs is approximately (3.4 nm / turn) / (10.5 bp / turn) = 0.324 nm / bp. Calculating sheet length: The length of a "sheet" can be calculated using simple trigonometry. We assumed that the diameter d of a coil is 3.0 nm.

Design 1: Single-Ply Lid Cylinder

Design 1 (cont.)

Design 2: Double-Ply Lid Cylinder

Design 2 (cont.) ASCII Representation

Design 3: Cube w/ Hinged Lids

Design 3 (cont.)

Plans for the Near Future Determine oligos needed Check each others’ oligos redundantly Order oligos; fold; visualize for efficacy Conduct thrombin-aptamer binding assays (simultaneously) Repeat steps 1-3 for oligos coded with aptamer sequences (within and without)