Fig. 2. SRS and traditional microscopy of intrinsic brain tumors.

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Fig. 2. SRS and traditional microscopy of intrinsic brain tumors. SRS and traditional microscopy of intrinsic brain tumors. (A) SRS imaging of a glioblastoma multiforme (GBM) (arrowhead) demonstrating ring enhancement on MRI. (B) Hypercellularity and nuclear atypia of viable tumor are apparent on both SRS (left) and H&E (right) microscopy. (C) Microvascular proliferation creates tortuous vascular complexes evident on SRS microscopy (left, arrowheads) and highlighted with periodic acid–Schiff staining (right, arrowhead). (D) Mitotic figures are also visible (arrowheads) with SRS microscopy (left) and H&E staining (right). (E and F) A non-enhancing, low-grade oligodendroglioma (arrowhead) (E) consists of hypercellular tissue with nests of “fried egg” morphology (arrowheads) (F) causing minimal axonal disruption on SRS imaging (left), as confirmed through neurofilament immunostaining (right). (G and H) “Chicken wire” blood vessels (arrowheads) imaged with SRS (left) and H&E (right) microscopy (G), and perineuronal satellitosis is visible in both SRS (left) and H&E (right) microscopy (H). Minbiao Ji et al., Sci Transl Med 2015;7:309ra163 Published by AAAS