From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

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From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells Ethan M. Shevach  Immunity  Volume 25, Issue 2, Pages 195-201 (August 2006) DOI: 10.1016/j.immuni.2006.08.003 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Multiple Flavors of T Regulatory Cells Several different types of T regulatory cells have been described in the literature. In addition to the “classic” CD4+Foxp3+ thymic-derived T regulatory cells, a similar population can be induced extrathymically in the presence of TGF-β or other stimuli. CD8+ T regulatory cells have been poorly characterized. It is not clear how the multiple types are related. Immunity 2006 25, 195-201DOI: (10.1016/j.immuni.2006.08.003) Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 2 Potential Suppressor-Effector Mechanisms Utilized by Treg Cells Three potential pathways by which T regulatory cells can mediate their suppressive effects on a number of different types of target cells including effector T cells, antigen-presenting cells (APCs), and B cells. Two of the pathways involve direct suppression of the target cells, whereas the secretion of suppressor cytokines may lead to bystander suppression. Immunity 2006 25, 195-201DOI: (10.1016/j.immuni.2006.08.003) Copyright © 2006 Elsevier Inc. Terms and Conditions