Embryo multinucleation at the two-cell stage is an independent predictor of intracytoplasmic sperm injection outcomes Laurent Desch, M.D., Céline Bruno,

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Presentation transcript:

Embryo multinucleation at the two-cell stage is an independent predictor of intracytoplasmic sperm injection outcomes Laurent Desch, M.D., Céline Bruno, M.D., Maxime Luu, M.D., Julie Barberet, Pharm.D., Cécile Choux, M.D., Marjorie Lamotte, M.D., Emeline Schmutz, M.D., Paul Sagot, M.D., Patricia Fauque, M.D., Ph.D. Fertility and Sterility Volume 107, Issue 1, Pages 97-103.e4 (January 2017) DOI: 10.1016/j.fertnstert.2016.09.022 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Implantation and birth rates according to the nuclear status at the two-cell stage. MNB2cell = multinucleated embryo at the two-cell stage; MNB1/2cell = only one multinucleated blastomere at the two-cell stage; MNB2/2cell = both blastomeres multinucleated at the two-cell stage. *P<.05, χ2 test. Fertility and Sterility 2017 107, 97-103.e4DOI: (10.1016/j.fertnstert.2016.09.022) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Loss rates of gestational sacs were compared (A) according to nuclear status at the two-cell stage among all transferred embryos (n = 608); and (B) according to the time to cleavage into four cells (T4, before or after 37 hours) among implanted MNB2cell embryos (χ2 test, P<.05). Fertility and Sterility 2017 107, 97-103.e4DOI: (10.1016/j.fertnstert.2016.09.022) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Kinetics of implanted MNB2cell embryos. Kinetics (tPNf, T2, T3, T4) of implanted embryos according to the nuclear status at the two-cell stage and their outcomes. Values are expressed in hours after ICSI. LGS = loss of gestational sac; MNB2cell = embryo multinucleated at the two-cell stage; MNB2/2cell = both blastomeres multinucleated at the two-cell stage; tPNf = stage of the two pronuclei fading; T2 = time to appearance of two cells; T3 = time to appearance of three cells; T4 = time to appearance of four cells. Fertility and Sterility 2017 107, 97-103.e4DOI: (10.1016/j.fertnstert.2016.09.022) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions