A Phosphoinositide Code for Primary Cilia

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A Phosphoinositide Code for Primary Cilia Fubito Nakatsu Developmental Cell Volume 34, Issue 4, Pages 379-380 (August 2015) DOI: 10.1016/j.devcel.2015.08.008 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Phosphoinositide Regulation at Distinct Cellular Membranes (A) Phosphoinositides known to localize at distinct cellular membranes are depicted. Note that both PI4P and PI(4,5)P2 are concentrated throughout the plasma membrane. (B) Model for regulation of Hh signaling proteins by phosphoinositide metabolism at primary cilia. Normally, INPP5E keeps PI(4,5)P2 levels low or at a minimum to tightly control the trafficking of Hh proteins at primary cilia (left). In INPP5E-deficient primary cilia, a PI(4,5)P2-effector Tulp3 and its binding partners Gpr161 and IFT-A accumulate upon PI(4,5)P2 buildup, leading to impairment of Hh signaling (right). See text for details. Developmental Cell 2015 34, 379-380DOI: (10.1016/j.devcel.2015.08.008) Copyright © 2015 Elsevier Inc. Terms and Conditions