Brian R Bond, PhD, James L Zellner, MD, B

Slides:

Advertisements

Similar presentations

Aprotinin improves pulmonary function during reperfusion in an isolated lung model Menen A Mathias, MD, Curtis G Tribble, MD, Jeffrey F Dietz, BS, Richard.

Advertisements

Twenty-Five Year Experience With the St

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD,

Leena Khaitan, MD, Francis P Sutter, Scott M Goldman, MD

Stroke after coronary artery operation: incidence, correlates, outcome, and cost John D Puskas, MD, A.Daniel Winston, MD, Carolyn E Wright, MS, John Parker.

Endothelium-Dependent Vasoconstriction in Isolated Vessel Grafts: A Novel Mechanism of Vasospasm? Markus Hoenicka, PhD, Andreas Keyser, MD, Leopold Rupprecht,

Vasorelaxation Induced by New Third-Generation Dihydropyridine Calcium Antagonist Azelnidipine in Human Internal Mammary Artery Ge Gao, MD, PhD, Xiao-Cheng.

Sternal Nourishment in Various Conditions of Vascularization

Thomas V Bilfinger, MD, George B Stefano, PhD

James A Haugen, MBA, George E Miller, MD

The Fontan Procedure in Adults

Clinical and Potential Use of Pharmacological Agents to Reduce Radial Artery Spasm in Coronary Artery Surgery Saina Attaran, MD, Lindsay John, MD, Ahmed.

Effect of the two new calcium channel blockers mebudipine and dibudipine on vascular flow of isolated kidney of normal and diabetic rats Lili Sepehr-Ara,

Differential Effects of Protein Kinase C Isoform Activation in Endothelin-Mediated Myocyte Contractile Dysfunction With Cardioplegic Arrest and Reperfusion

Calcium-Channel Blockers Preserve Coronary Endothelial Reactivity After Ischemia- Reperfusion François Dagenais, MD, Raymond Cartier, MD, Charleen Hollmann,

Guo-Wei He, MD, PhD, Cheng-Qin Yang, MD

Interaction between vasodilators and vasopressin in internal mammary artery and clinical significance Wei Wei, MD, H.Storm Floten, MD, Guo-Wei He, MD,

Regulation of Human Internal Mammary and Radial Artery Contraction by Extracellular and Intracellular Calcium Channels and Cyclic Adenosine 3′, 5′ Monophosphate

Oz M. Shapira, MDa, Aiming Xu, PhDb, Joseph A. Vita, MDb, Gabriel S

James L Zellner, MD, Scott B Kribbs, BS, B

Expression and Function of Endothelial Nitric Oxide Synthase Messenger RNA and Protein Are Higher in Internal Mammary Than in Radial Arteries Guo-Wei.

Michelle C. Ellis, MD, Brian S. Diggs, PhD, John T. Vetto, MD, Paul H

Muhammad Arshad, MD, Venkataramana Vijay, MD, Beverly C

Hypomagnesemia Inhibits Nitric Oxide Release From Coronary Endothelium: Protective Role of Magnesium Infusion After Cardiac Operations1 Paul J. Pearson,

Surgical Resection of a Giant Coronary Aneurysm

Intravenous Diltiazem and Acute Renal Failure After Cardiac Operations

Shigeyuki Sasaki, MD, PhD (by invitation), James D

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

The heart string: a simple, inexpensive exposure of the heart during coronary artery operations Hiroshi Niinami, MD, PhD, Hitoshi Koyanagi, MD, Peter.

Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: An 8-year retrospective.

Use of Recombinant Activated Factor VII Concentrate to Control Postoperative Hemorrhage in Complex Cardiovascular Surgery Lyndsey J. Bowman, Walter E.

John S. Ikonomidis, MD, PhD, Ebony J

Aprotinin Exerts Differential and Dose-Dependent Effects on Myocardial Contractility, Oxidative Stress, and Cytokine Release After Ischemia-Reperfusion

The Joint Council on Thoracic Surgery Education Coronary Artery Assessment Tool Has High Interrater Reliability Richard Lee, MD, MBA, Daniel Enter, MD,

Perioperative cardiac function and predictors for adverse events after transmyocardial laser treatment Ole Tjomsland, MD, Lars Aaberge, MD, Sven M Almdahl,

Anomalous Origin of Left Pulmonary Artery From Left Subclavian Artery

John.S Ikonomidis, MD, PhD, Robert C Robbins, MD

Endothelin-1 during and after cardiopulmonary bypass: Association to graft sensitivity and postoperative recovery Brian R. Bond, PhD, B.Hugh Dorman,

Pathology of the Radial and Internal Thoracic Arteries Used as Coronary Artery Bypass Grafts Eric Kaufer, BS, Stephen M Factor, MD, Rosemary Frame, MS,

Twenty-year experience with the St Jude Medical mechanical valve prosthesis John S Ikonomidis, MD, PhD, John M Kratz, MD, Arthur J Crumbley, MD, Martha.

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD,

Cassandra Joffs, MD, Himali R. Gunasinghe, BS, Marlina M

Editorial Board, January 2010

A new antispastic solution for arterial grafting: Nicardipine and nitroglycerin cocktail in preparation of internal thoracic and radial arteries for coronary.

Pretreatment with 3,5,3′ triiodo-l-thyronine (t3): Effects on myocyte contractile function after hypothermic cardioplegic arrest and rewarming Jennifer.

Vacuum-Assisted Closure for the Treatment of Complex Chest Wounds

Safety and efficacy of a heparin removal device: a prospective randomized preclinical outcomes study Joseph B Zwischenberger, MD, Weike Tao, MD, Donald.

Christine S. Rinder, MD, Michael J. Smith, PhD, Henry M

Role of Endothelin-1 Receptor Antagonists in Vasoconstriction Mediated by Endothelin and Other Vasoconstrictors in Human Internal Mammary Artery Guo-Wei.

Ronald A. Bronicki, MD, Carl L. Backer, MD, Harris P

Nitric Oxide Dose Response During Moderate and Severe Hypoxia in Swine

Is the kaolin or celite activated clotting time affected by tranexamic acid? J.F.Matthias Bechtel, MD, Joachim Prosch, Hans-Hinrich Sievers, MD, Claus.

Stephanie B. Clayton, PharmD, Jeffrey R. Acsell, CCP, Arthur J

Survival After Isolated Coronary Artery Bypass Grafting in Patients With Severe Left Ventricular Dysfunction Waleed A. Ahmed, MD, Phillip J. Tully, BHSc(Hons),

Invited Commentary The Annals of Thoracic Surgery

Randomized Controlled Trial of Pericardial Blood Processing With a Cell-Saving Device on Neurologic Markers in Elderly Patients Undergoing Coronary Artery.

Neal S Goldstein, MD The Annals of Thoracic Surgery

Daryl L. Reust, MD, Scott T. Reeves, MD, James H

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Sérgio A de Oliveira, MD The Annals of Thoracic Surgery

Rachael L. Ford, BS, Ira M. Mains, BS, Ebony J. Hilton, BS, Scott T

Prevention of radial artery graft vasospasm after coronary bypass

Arterial balloon catheter: a new atraumatic device for dilating arterial grafts Hugues Jeanmart, MD, Louis P Perrault, MD, PhD, Nathalie Desjardins, BS,

An alternative method of neck flexion after tracheal resection

Late Consequences of a Much Earlier Decision

Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.

Erik Madssen, RF, Petter Haere, MD, Rune Wiseth, MD, PhD

Heart Transplant Program Volume Is Not a Measure of Quality

A randomized trial of antithrombin concentrate for treatment of heparin resistance Mathew R Williams, MD, Alyssa B D’Ambra, BA, James R Beck, Talia B.

J. Alberto Lopez, MD The Annals of Thoracic Surgery

Presentation transcript:

Differential effects of calcium channel antagonists in the amelioration of radial artery vasospasm Brian R Bond, PhD, James L Zellner, MD, B.Hugh Dorman, MD, PhD, Marlina M Multani, BS, John M Kratz, MD, Arthur J Crumbley, MD, Fred A Crawford, MD, Francis G Spinale, MD, PhD The Annals of Thoracic Surgery Volume 69, Issue 4, Pages 1035-1040 (April 2000) DOI: 10.1016/S0003-4975(00)01132-2

Fig 1 Endothelin tension response curves were generated from RA samples (n = 4) exposed to increasing concentrations of endothelin (0.1 to 100 nM). These curves allowed for the computation of the concentration of endothelin necessary to induce 50% of maximal vasoconstriction (EC50 = 8.5 ± 1.2 nM). The concentration of endothelin used in subsequent RA experiments (10 nM) was based upon this EC50 value. The Annals of Thoracic Surgery 2000 69, 1035-1040DOI: (10.1016/S0003-4975(00)01132-2)

Fig 2 Norepinephrine tension response curves were generated from RA samples (n = 13). Norepinephrine (1 μM) induced a time-dependent increase in RA developed tension that reached a plateau value after 5 minutes. The Annals of Thoracic Surgery 2000 69, 1035-1040DOI: (10.1016/S0003-4975(00)01132-2)

Fig 3 The percent reduction in endothelin-induced RA developed tension with calcium channel antagonist treatment with diltiazem (125 ng/mL; n = 13), amlodipine (30 ng/mL; n = 13), and nifedipine (50 ng/mL; n = 10). Diltiazem did not significantly alter endothelin-induced vasoconstriction (p = 0.32 vs baseline). However, amlodipine or nifedipine significantly reduced endothelin-mediated vasoconstriction (∗p < 0.05 vs baseline). In addition, both amlodipine and nifedipine significantly reduced endothelin-mediated RA vasoconstriction when compared with diltiazem (#p < 0.05 vs diltiazem). The Annals of Thoracic Surgery 2000 69, 1035-1040DOI: (10.1016/S0003-4975(00)01132-2)

Fig 4 The percent reduction in norepinephrine-induced RA developed tension with calcium channel antagonist treatment with diltiazem (125 ng/mL; n = 13), amlodipine (30 ng/mL; n = 13), and nifedipine (50 ng/mL; n = 10). Diltiazem did not significantly alter norepinephrine-induced vasoconstriction (p = 0.86 vs baseline). However, amlodipine and nifedipine significantly reduced norepinephrine-mediated vasoconstriction (∗p < 0.05 vs baseline). In addition, both amlodipine and nifedipine significantly reduced norepinephrine-mediated RA vasoconstriction when compared with diltiazem (#p < 0.05 vs diltiazem). The Annals of Thoracic Surgery 2000 69, 1035-1040DOI: (10.1016/S0003-4975(00)01132-2)