Volume 125, Issue 4, Pages (October 2003)

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Volume 125, Issue 4, Pages 1094-1104 (October 2003) Low microvessel density is an unfavorable histoprognostic factor in pancreatic endocrine tumors Anne-Marie Marion-Audibert, Cécile Barel, Géraldine Gouysse, Jérôme Dumortier, Frank Pilleul, Céline Pourreyron, Valérie Hervieu, Gilles Poncet, Catherine Lombard-Bohas, Jean-Alain Chayvialle, Christian Partensky, Jean-Yves Scoazec Gastroenterology Volume 125, Issue 4, Pages 1094-1104 (October 2003) DOI: 10.1016/S0016-5085(03)01198-3

Figure 1 Immunohistochemical results. Two examples of CD34 immunostaining of endocrine pancreatic tumors are shown in A and B; in A, intratumoral microvascular density is high: CD34+ structures are numerous and small; in B, intratumoral microvascular density is low: CD34+ structures are rare and large. In normal Langerhans’ islets (arrow), capillary vessels are characterized by a faint and heterogeneous expression of CD34 (C) and of the smooth muscle isoform of α actin (D). In contrast, the smooth muscle isoform of α actin is strongly detectable along intratumoral capillary vessels and in the wall of arterioles (arrow) (E). (Immunoperoxidase followed by nuclear staining with Mayer’s hematoxylin; original magnifications: A, 200×; B, 200×; C, 350×; D, 350×; E, 200×). Gastroenterology 2003 125, 1094-1104DOI: (10.1016/S0016-5085(03)01198-3)

Figure 2 Correlation between intratumoral microvascular density and tumor size. Gastroenterology 2003 125, 1094-1104DOI: (10.1016/S0016-5085(03)01198-3)

Figure 3 Intratumoral microvascular density (MVD) (mean ± SD) in pancreatic endocrine tumors according to the hormonal status. Gastroenterology 2003 125, 1094-1104DOI: (10.1016/S0016-5085(03)01198-3)

Figure 4 Survival curves (according to Kaplan-Meier) for all the patients of the study group according to intratumoral microvascular density < 30 (open circles) or > 30 (open squares); P < 0.05 (log-rank test). Gastroenterology 2003 125, 1094-1104DOI: (10.1016/S0016-5085(03)01198-3)