Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD,

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Presentation transcript:

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium- dependent mechanism Marilyn J. Cipolla, PhD, Alexander Nicoloff, MD, Tessio Rebello, PhD, Anthony Amato, MD, John M. Porter, MD Journal of Vascular Surgery Volume 29, Issue 6, Pages 1097-1103 (June 1999) DOI: 10.1016/S0741-5214(99)70251-X Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Diameter tracing of an intact human subcutaneous artery contracted with norepinephrine and given increasing concentrations of propionyl-L-carnitine. Note that propionyl-L-carnitine caused concentration-dependent vasodilation of this artery. Journal of Vascular Surgery 1999 29, 1097-1103DOI: (10.1016/S0741-5214(99)70251-X) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Diameter tracing of a denuded human subcutaneous artery contracted with norepinephrine and given increasing concentrations of propionyl-L-carnitine. Note that propionyl-L-carnitine had considerably less effect on the diameter of this artery. Journal of Vascular Surgery 1999 29, 1097-1103DOI: (10.1016/S0741-5214(99)70251-X) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Graph of the concentration-response curves to propionyl-L-carnitine of intact, intact and in the presence of 0.1 mmol/L L-NNA or 10.0 μmol/L indomethacin, and denuded human arteries. Note that propionyl-L-carnitine caused concentration-dependent vasodilation in intact arteries, but had little effect on deendothelialized arteries. Arteries in the presence of L-NNA dilated to a similar degree as intact arteries; however, the presence of indomethacin significantly reduced this vasodilation. *P < .05; **P < .01 vs. intact. Journal of Vascular Surgery 1999 29, 1097-1103DOI: (10.1016/S0741-5214(99)70251-X) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Graph of the percent dilation of intact, intact and in the presence of 0.1 mmol/L nitro-L-arginine or 10.0 mmol/L indomethacin, and denuded human arteries in the highest concentration of propionyl-L-carnitine (10–4 mol/L). ** P < .01 vs. intact. Journal of Vascular Surgery 1999 29, 1097-1103DOI: (10.1016/S0741-5214(99)70251-X) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions