New method for absolute spinal cord ischemia protection in rabbits

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Presentation transcript:

New method for absolute spinal cord ischemia protection in rabbits Bagus Herlambang, MD, Kazumasa Orihashi, MD, PhD, Taketomo Mizukami, MD, PhD, Shinya Takahashi, MD, PhD, Naomichi Uchida, MD, PhD, Eiso Hiyama, MD, PhD, Taijiro Sueda, MD, PhD Journal of Vascular Surgery Volume 54, Issue 4, Pages 1109-1116 (October 2011) DOI: 10.1016/j.jvs.2011.04.043 Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 1 Injection of edaravone or saline into the clamped segment of aorta. The abdominal aorta was clamped just distal to the renal artery and at the aortic bifurcation. Edaravone or saline was injected through an elastic catheter into the clamped segment of aorta. Journal of Vascular Surgery 2011 54, 1109-1116DOI: (10.1016/j.jvs.2011.04.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 2 The transvertebral cooling pad was placed in the abdominal cavity on the peritoneum, lying on the left side of vertebral bodies at the levels of L1 to L5, between the aorta and psoas muscle, during aortic clamping. Journal of Vascular Surgery 2011 54, 1109-1116DOI: (10.1016/j.jvs.2011.04.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 3 Changes in the lumbar vertebrae temperature are shown during 30 minutes of aortic clamping and 10 minutes after reperfusion (mean ± standard deviation). Journal of Vascular Surgery 2011 54, 1109-1116DOI: (10.1016/j.jvs.2011.04.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 4 The Tarlov scores are shown at 8, 24, 48, and 168 hours after reperfusion (mean ± standard deviation). Journal of Vascular Surgery 2011 54, 1109-1116DOI: (10.1016/j.jvs.2011.04.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 5 Histopathologic findings of the spinal cord are shown at 48 hours (subgroup A) and at 168 hours (subgroup B) after reperfusion (hematoxylin and eosin staining; original magnification, ×200). I-A and I-B, sham-operated rabbits; II-A and II-B, edaravone-treated rabbits; III-A and III-B, rabbits treated with saline and transvertebral cooling pad; IV-A and IV-B, rabbits treated with edaravone and transvertebral cooling pad. Arrows, normal motor neurons; arrowheads, ischemic neurons (the cell body was shrunken; pyknotic nucleus; the cytoplasm became eosinophilic, with loss of Nissl granules). Journal of Vascular Surgery 2011 54, 1109-1116DOI: (10.1016/j.jvs.2011.04.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 5 Histopathologic findings of the spinal cord are shown at 48 hours (subgroup A) and at 168 hours (subgroup B) after reperfusion (hematoxylin and eosin staining; original magnification, ×200). I-A and I-B, sham-operated rabbits; II-A and II-B, edaravone-treated rabbits; III-A and III-B, rabbits treated with saline and transvertebral cooling pad; IV-A and IV-B, rabbits treated with edaravone and transvertebral cooling pad. Arrows, normal motor neurons; arrowheads, ischemic neurons (the cell body was shrunken; pyknotic nucleus; the cytoplasm became eosinophilic, with loss of Nissl granules). Journal of Vascular Surgery 2011 54, 1109-1116DOI: (10.1016/j.jvs.2011.04.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 6 Number of normal motor neurons in the anterior horn of lumbar spinal cord in a specimen slice are shown at 48 and 168 hours after reperfusion (mean ± standard deviation). Journal of Vascular Surgery 2011 54, 1109-1116DOI: (10.1016/j.jvs.2011.04.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 7 Malondialdehyde (MDA) levels in the lumbar spinal cord are shown at 48 and 168 hours after reperfusion (mean ± standard deviation). Journal of Vascular Surgery 2011 54, 1109-1116DOI: (10.1016/j.jvs.2011.04.043) Copyright © 2011 Society for Vascular Surgery Terms and Conditions