Serum Vitamin C (mg/dl) by Salad Intake

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Serum Vitamin C (mg/dl) by Salad Intake Vitamin D Status and Associations in Newborn, Formula Fed Infants During Initial Hospitalization Corrine Hanson, PhD, RD: University of Nebraska Medical Center (UNMC) Laura Armas, MD: Creighton University Elizabeth Lyden, MS: UNMC Ann Anderson-Berry, MD: UNMC JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION Hanson, et al. J Am Diet Assoc. 2011; 111 (December).

Serum Vitamin C (mg/dl) by Salad Intake Vitamin D Status and Associations in Newborn, Formula Fed Infants During Initial Hospitalization Study Objective Serum Vitamin C (mg/dl) by Salad Intake To examine the vitamin D status in population of hospitalized infants who receive standard formula feedings with and without supplemental vitamin D during their stay in the Newborn Intensive Care Nursery (NICU) Infants were randomized to two groups: One group received 400 International Units vitamin D3 in addition to formula, one group received a placebo. Fifty-six formula fed, NICU hospitalized infants with a gestational age of 32 weeks or greater were enrolled over 1 year JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION Hanson, et al. J Am Diet Assoc. 2011; 111 (December).

Serum Vitamin C (mg/dl) by Salad Intake Vitamin D Status and Associations in Newborn, Formula Fed Infants During Initial Hospitalization Serum Vitamin C (mg/dl) by Salad Intake 25(OH)D Levels were measured on Cord Blood at birth The mean cord blood level was 17.6 ng/mL There was no statistical significance in the 25(OH)D levels of the cord blood between mothers who reported taking or not taking prenatal vitamins (p=0.10) White infants had statistically higher mean cord blood levels than non-white infants ( 21.1 vs. 13.7 ng/ml, p=0.0001). A positive association existed between cord blood 25(OH)D levels and serum calcium levels in the first week of life (r=0.44, p=0.003) Cord blood levels also positively correlated with gestational age (r=0.35, p=0.015) JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION Hanson, et al. J Am Diet Assoc. 2011; 111 (December).

Serum Vitamin C (mg/dl) by Salad Intake Vitamin D Status and Associations in Newborn, Formula Fed Infants During Initial Hospitalization Vitamin D status over the NICU hospitalization Serum Vitamin C (mg/dl) by Salad Intake There was an overall significant change in 25(OH)D levels over 14 days (p=0.0001) for infants in the NICU. The supplemented group had higher 25(OH)D levels at day 7 compared to cord blood (p=0.0001), and day 14 compared to day 7 (p=0.04). The placebo group showed increasing 25(OH)D levels, however the effect lessened with time (cord blood vs day 14, p=.022, day 7 vs day 14, p=0.35) JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION Hanson, et al. J Am Diet Assoc. 2011; 111 (December).

Serum Vitamin C (mg/dl) by Salad Intake Vitamin D Status and Associations in Newborn, Formula Fed Infants During Initial Hospitalization Serum Vitamin C (mg/dl) by Salad Intake Change in 25 (OH)D levels (ng/mL), by randomization group JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION Hanson, et al. J Am Diet Assoc. 2011; 111 (December).

Serum Vitamin C (mg/dl) by Salad Intake Vitamin D Status and Associations in Newborn, Formula Fed Infants During Initial Hospitalization Serum Vitamin C (mg/dl) by Salad Intake 25(OH)D Levels at Discharge The mean 25(OH)D level of both groups remained below 30 ng/mL at discharge. Treated group: 23.1+ 7.0 ng/mL Placebo group: 17.8+4.7 ng/mL (p=0.007). The mean 25(OH)D levels at discharge of the treated group was significantly higher than the placebo group (p=0.007). There was a statistically significant difference in the mean 25(OH)D levels between white and non-white infants at discharge (23.13+6.66 vs. 17.33+4.62 ng/mL, p=0.0013). 25(OH)D levels showed a statistically significant negative correlation with parathyroid hormone levels (r=-0.35, p=0.02). JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION Hanson, et al. J Am Diet Assoc. 2011; 111 (December).

Serum Vitamin C (mg/dl) by Salad Intake Vitamin D Status and Associations in Newborn, Formula Fed Infants During Initial Hospitalization Summary of 25(OH)D levels over time, by randomization and race Serum Vitamin C (mg/dl) by Salad Intake 25(OH)D Mean +SD All Infants White Infants Non-white Infants P-values Supplement Infants Placebo Infants Cord Blood 17.6+7.0 21.1+6.4 13.7+5.5 0.0001 19.1+7.7 16.3+6.14 0.19 Range 6.8-37.5 11.8-37.5 6.8-30.1 7.7-30.1 Number of Subjects 47 25 22 23 24 Day 7 19.4+5.67 22.4+6.3 16.4+2.9 0.0014 21.4+6.8 17.5+3.6 11.2-36.1 11.3-21 12.3-36.1 11.2-25 Number of subjects 38 20 18 Day 14 20.9+6.1 23.8+6.7 17.4+1.7 24.4+7.4 18.1+2.7 13.1-36.8 14.6-21.0 0.02 14.6-36.8 13.1-22.4 11 9 Day 21 17.2+3.1 12.3-20.9 6 Discharge 20.4+6.5 23.1+6.7 17.3+4.6 0.001 23.1+7.0 17.8+4.7 0.007 9.9-37.5 13.1-37.5 9.9-30.1 12.3-37.5 50 27 JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION Hanson, et al. J Am Diet Assoc. 2011; 111 (December).

Serum Vitamin C (mg/dl) by Salad Intake Vitamin D Status and Associations in Newborn, Formula Fed Infants During Initial Hospitalization Conclusions Serum Vitamin C (mg/dl) by Salad Intake Given vitamin D’s relationship with bone health and associations found in this study with hypocalcemia and elevated PTH, consideration should be given to supplementing preterm, formula fed infants in the NICU to achieve desirable 25(OH)D concentrations during their initial hospitalization. JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION Hanson, et al. J Am Diet Assoc. 2011; 111 (December).