Activation of the innate immune response may be radioprotective during larval development. Activation of the innate immune response may be radioprotective.

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Activation of the innate immune response may be radioprotective during larval development. Activation of the innate immune response may be radioprotective during larval development. For each dose of radiation, the percentage of irradiated third instar larvae that complete development and eclose as adults is shown for the indicated genotypes. Loss of both Toll and Imd signaling (RelE20 spz4) or Toll signaling alone (spz4) results in increased sensitivity to radiation compared with controls. Each bar represents mean ± SEM for two to five trials with 20–40 larvae per trial. ***P < 0.001 based on Student’s t-test comparing RelE20 spz4 40 Gy or spz4 40 Gy to w1118 40 Gy. *P < 0.05 based on Student’s t-test comparing spz4 30 Gy to w1118 30 Gy. Lisa J. Sudmeier et al. G3 2015;5:2299-2306 ©2015 by Genetics Society of America