Von Willebrand Factor Receptor GPIbα is Expressed by Human Factor XIIIa-Positive Dermal Dendrocytes and is Upregulated by Mast Cell Degranulation Marcia.

Slides:

Advertisements

Similar presentations

Reduced Tumor Necrosis Factor-α and Transforming Growth Factor-β1 Expression in the Lungs of Inbred Mice that Fail to Develop Fibroproliferative Lesions.

Advertisements

Mihaela Skobe, Michael Detmar

Ultraviolet B-Induced Skin Angiogenesis Is Associated with a Switch in the Balance of Vascular Endothelial Growth Factor and Thrombospondin-1 Expression

Ultrastructural analysis of human skin biopsy specimens from patients receiving recombinant human stem cell factor: Subcutaneous injection of rhSCF induces.

Volume 108, Issue 1, Pages (July 1995)

Mihaela Skobe, Michael Detmar

Fibroblast Activation Protein: Differential Expression and Serine Protease Activity in Reactive Stromal Fibroblasts of Melanocytic Skin Tumors Margit.

Possible Involvement of Basement Membrane Damage in Skin Photoaging

The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

BM-40(Osteonectin, SPARC) Is Expressed Both in the Epidermal and in the Dermal Compartment of Adult Human Skin Nicholas Hunzelmann, Martin Hafner, Sabine.

Focal Dermal–Epidermal Separation and Fibronectin Cleavage in Basement Membrane by Human Mast Cell Tryptase Renata Kaminska, Petra Helisalmi, Rauno J.

Establishment of Rat Dermal Papilla Cell Lines that Sustain the Potency to Induce Hair Follicles from Afollicular Skin Mutsumi Inamatsu, Takashi Matsuzaki,

John E. Olerud, Diane S. Chiu, Marcia L. Usui

Transcriptional and Cytokine Profiles Identify CXCL9 as a Biomarker of Disease Activity in Morphea Jack C. O’Brien, Yevgeniya Byekova Rainwater, Neeta.

A Three-Dimensional Atlas of Human Dermal Leukocytes, Lymphatics, and Blood Vessels Xiao-Nong Wang, Naomi McGovern, Merry Gunawan, Connor Richardson,

Connexins 26, 30, and 43: Differences Among Spontaneous, Chronic, and Accelerated Human Wound Healing Johanna M. Brandner, Pia Houdek, Birgit Hüsing,

Localization, Age- and Site-Dependent Expression, and Regulation of 11β- Hydroxysteroid Dehydrogenase Type 1 in Skin Ana Tiganescu, Elizabeth A. Walker,

Overexpression of Serpin Squamous Cell Carcinoma Antigens in Psoriatic Skin Atsushi Takeda, Dousei Higuchi, Tadahito Takahashi, Masashi Ogo, Peter Baciu,

Loss of EPC-1/PEDF Expression During Skin Aging In Vivo

Paul G. Genever, Sarah J. Maxfield, Tim M. Skerry

Marie-Thérèse Leccia Journal of Investigative Dermatology

The Spatial and Temporal Expression Patterns of Integrin α9β1 and One of Its Ligands, the EIIIA Segment of Fibronectin, in Cutaneous Wound Healing Purva.

Herpes Simplex Virus Associated Erythema Multiforme (HAEM) is Mechanistically Distinct from Drug-Induced Erythema Multiforme: Interferon-γ is Expressed.

Massive Recruitment of Type I Interferon Producing Plasmacytoid Dendritic Cells in Varicella Skin Lesions Gianni Gerlini, Giulia Mariotti, Beatrice Bianchi,

Spontaneous Regression of Highly Immunogenic Molluscum contagiosum Virus (MCV)- Induced Skin Lesions Is Associated with Plasmacytoid Dendritic Cells and.

Jo-Ellen Murphy, Caroline Robert, Thomas S. Kupper

C-Terminus of Desmoyokin/AHNAK Protein is Responsible for its Translocation Between the Nucleus and Cytoplasm Zhuxiang Nie, Takashi Hashimoto Journal.

Assembly of Epithelial Cell Fibrillins

Normalization of Epidermal Calcium Distribution Profile in Reconstructed Human Epidermis Is Related to Improvement of Terminal Differentiation and Stratum.

Inhibition of Hair Follicle Growth by a Laminin-1 G-Domain Peptide, RKRLQVQLSIRT, in an Organ Culture of Isolated Vibrissa Rudiment1 Kazuhiro Hayashi,

Characterization of the Progressive Skin Disease and Inflammatory Cell Infiltrate in Mice with Inhibited NF-κB Signaling Max van Hogerlinden, Barbro.

Toshiyuki Yamamoto, Kiyoshi Nishioka

Light and Electron Microscopic Demonstration of the p75 Nerve Growth Factor Receptor in Normal Human Cutaneous Nerve Fibers: New Vistas Yong Liang, Olle.

A Short-Term Screening Protocol, Using Fibrillin-1 as a Reporter Molecule, for Photoaging Repair Agents Rachel E.B. Watson, Nicholas M. Craven, Christopher.

The Complexity of Elastic Fiber Biogenesis: The Paradigm of Cutis Laxa

Low-Frequency Sonophoresis: Ultrastructural Basis for Stratum Corneum Permeability Assessed Using Quantum Dots Sumit Paliwal, Gopinathan K. Menon, Samir.

Changing Pattern of Deiminated Proteins in Developing Human Epidermis

Michelle E. Oakford, Sandra V

Mutant Loricrin is Not Crosslinked into the Cornified Cell Envelope but is Translocated into the Nucleus in Loricrin Keratoderma Akemi Ishida-Yamamoto,

Francois le Pelletier, Anne Janin Journal of Investigative Dermatology

Human Glands of Moll: Histochemical and Ultrastructural Characterization of the Glands of Moll in the Human Eyelid Beate M. Stoeckelhuber Journal of.

Sheet Preparations Expose the Dermal Nerve Plexus of Human Skin and Render the Dermal Nerve End Organ Accessible to Extensive Analysis Erwin Tschachler,

Molecular Architecture of Tight Junctions of Periderm Differs From That of the Maculae Occludentes of Epidermis Kazumasa Morita, Yoko Yoshida, Yoshiki.

A Close-Up View of Migrating Langerhans Cells in the Skin

Histological Characterization of Cutaneous Nerve Fibers Containing Gastrin-Releasing Peptide in NC/Nga Mice: An Atopic Dermatitis Model Mitsutoshi Tominaga,

Protease-Activated Receptor 2, a Receptor Involved in Melanosome Transfer, is Upregulated in Human Skin by Ultraviolet Irradiation Glynis Scott, Cristina.

YAP and TAZ Regulate Skin Wound Healing

Periderm Cells Form Cornified Cell Envelope in Their Regression Process During Human Epidermal Development Masashi Akiyama Journal of Investigative.

The Cutaneous Microcirculation

John E. Olerud, Marcia L. Usui, Deniz Seckin, Diane S. Chiu, Claire L

Molecular Consequences of Deletion of the Cytoplasmic Domain of Bullous Pemphigoid 180 in a Patient with Predominant Features of Epidermolysis Bullosa.

Manabu Taniguchi, Shinsuke Matsuzaki, Masaya Tohyama

David Quigley Journal of Investigative Dermatology

Ushio Takeda, Atsushi Utani, Jinghai Wu, Hiroshi Shinkai

Ultraviolet B-Induced Skin Angiogenesis Is Associated with a Switch in the Balance of Vascular Endothelial Growth Factor and Thrombospondin-1 Expression

Normal Wound Healing in Mice Deficient for Fibulin-5, an Elastin Binding Protein Essential for Dermal Elastic Fiber Assembly Qian Zheng, Jiwon Choi,

Differential Effect of Wounding on Actin and its Associated Proteins, Paxillin and Gelsolin, in Fetal Skin Explants Allison J. Cowin, Nicholas Hatzirodos,

Detection of a Physiological Juvenile Phase and the Central Role of Pericytes in Human Dermal Microvascular Aging Peter Helmbold, Christine Lautenschläger,

Alterations in Fibroblast α1β1 Integrin Collagen Receptor Expression in Keloids and Hypertrophic Scars Greg Szulgit Journal of Investigative Dermatology

Salvador González, Robert Sackstein, R

Organization of Stem Cells and Their Progeny in Human Epidermis

The Expression of Vitamin D-Upregulated Protein 1 in Skin and its Interaction with Sciellin in Cultured Keratinocytes Marie-France Champliaud, Alain.

Expression of Mast Cell Growth Modulating and Chemotactic Factors and their Receptors in Human Cutaneous Scars Barbara Hermes Journal of Investigative.

An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression Diana.

Truncation of CGI-58 Protein Causes Malformation of Lamellar Granules Resulting in Ichthyosis in Dorfman-Chanarin Syndrome Masashi Akiyama, Daisuke Sawamura,

Human Glands of Moll: Histochemical and Ultrastructural Characterization of the Glands of Moll in the Human Eyelid Beate M. Stoeckelhuber Journal of.

Errata Journal of Investigative Dermatology

Marcos A. Antezana, Stephen R. Sullivan, Marcia L. Usui, John E

Rolf Hoffmann, Shiro Niiyama Journal of Investigative Dermatology

Ultrastructural analysis of human skin biopsy specimens from patients receiving recombinant human stem cell factor: Subcutaneous injection of rhSCF induces.

Presentation transcript:

Von Willebrand Factor Receptor GPIbα is Expressed by Human Factor XIIIa-Positive Dermal Dendrocytes and is Upregulated by Mast Cell Degranulation Marcia R. Monteiro, Diana W. Menezes, George F. Murphy Journal of Investigative Dermatology Volume 113, Issue 2, Pages 272-276 (August 1999) DOI: 10.1046/j.1523-1747.1999.00665.x Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Characterization of GPIbα-reactive dendritic cells in normal adult human skin. Immunohistochemistry for GPIbα demonstrates numerous positive cells with highly dendritic contours (arrows) within the superficial dermis (A), with concentration directly beneath the epidermis (e) (B) and about superficial vessels (v) lined by GPIbα-positive endothelium (A, C). By transmission electron microscopy (D) and correlative immunoelectron microscopy (E), GPIbα reactivity is restricted to interstitial cells characterized by elongate membranous flaps which in cross-section resembled dendrites and averaged 20–30 μm in length (arrowheads). Inset shows typical dendritic profile at higher magnification (insets: D, X12,000; E, X16,500). Note cytoplasmic and possible cell membrane immunoreactivity in E (unstained; Nu = nucleus). Cells similar in contour to GPIbα-reactive dermal dendrocytes (F) also react for FXIIIa in adjacent tissue sections (G); arrowheads denote elongated dendrite-like extensions. Co-expression of GPIbα and FXIIIa reactivity in dermal dendrocytes was achieved using confocal microscopy (H = GPIbα channel, I = FXIIIa channel). Scale bars: (A–C) 25 μm; (D) 2 μm; (E) 1 μm; (F, G) 10 μm; (H, I) 5 μm. Journal of Investigative Dermatology 1999 113, 272-276DOI: (10.1046/j.1523-1747.1999.00665.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Effects of mast cell degranulation on dermal dendritic cells coexpressing Factor XIIIa and GPIbα. Co-expression of these molecules is observed in dendritic cells (arrows) in the perivascular interstitium; note that endothelial cells within vessels (v) also stain for GPIbα (B) but not for factor XIIIa (A). Immunohistochemistry for GPIbα in neonatal foreskin organ culture at baseline (C) and 24 h after substance P-induced mast cell degranulation (D). Immunoreactivity for GPIbα on perivascular and interstitial dermal dendritic cells, as compared with baseline and control explants, is significantly increased 24 h after mast cell degranulation. Scale bar: 20 μm (A–D). Journal of Investigative Dermatology 1999 113, 272-276DOI: (10.1046/j.1523-1747.1999.00665.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Schematic representation of GPIb-IX-V complex and its components. Note the leucine-rich domain (LRD) located nearby the ligand-binding sites (LBS) for both von Willebrand factor and thrombin in the amino-terminal extracytoplasmic region of the GPIbα molecule. (modified fromLopez & Dong 1997) Journal of Investigative Dermatology 1999 113, 272-276DOI: (10.1046/j.1523-1747.1999.00665.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions