Temporal assessment of bone marrow lesions on magnetic resonance imaging in a canine model of knee osteoarthritis: impact of sequence selection M.-A.

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Temporal assessment of bone marrow lesions on magnetic resonance imaging in a canine model of knee osteoarthritis: impact of sequence selection M.-A. d'Anjou, D.M.V., Diplomate A.C.V.R., E. Troncy, D.V., Ph.D., D.Un., M. Moreau, M.Sc., F. Abram, Ph.D., J.-P. Raynauld, M.D., J. Martel-Pelletier, Ph.D., J.-P. Pelletier, M.D. Osteoarthritis and Cartilage Volume 16, Issue 11, Pages 1307-1311 (November 2008) DOI: 10.1016/j.joca.2008.03.022 Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Semi-quantitative grading scheme used to score BMLs in each subregion. Each BML was scored according to its extent in the volume of each subregion, individually on each of the three MRI sequences. Osteoarthritis and Cartilage 2008 16, 1307-1311DOI: (10.1016/j.joca.2008.03.022) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Distribution of signal changes on three different MRI sequences. In this dog, the BML (arrowheads) affecting the medial portion (MP) of the tibial plateau differed between sequences. The lesion was more intense deeper in the subchondral bone marrow on SPGR vs closer to the subchondral plate on T2-FS. It was uniformly hypointense, superficially and deeply, on T1-GRE. Signal changes extended into the central portion of the tibial plateau, as seen on the dorsal T1-GRE image. The interrupted line on T1-GRE indicates slice localization for sagittal SPGR and T2-FS images. Osteoarthritis and Cartilage 2008 16, 1307-1311DOI: (10.1016/j.joca.2008.03.022) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Temporal evolution of global BML scores (mean±SD) assessed on three MRI sequences in five dogs. Global BML scores where the average of both readings. Scores increased similarly on all three sequences between baseline and week 8, but progressed differently between week 8 and 26. *Global BML score significantly different compared to T1-GRE and SPGR. ¶Global BML score significantly different compared to baseline. §Global score significantly different compared to week 4. Osteoarthritis and Cartilage 2008 16, 1307-1311DOI: (10.1016/j.joca.2008.03.022) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions