Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil Camila Alexandrina.

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Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil Camila Alexandrina Figueiredo, PhD, Maurício Lima Barreto, MD, PhD, Neuza Maria Alcantara-Neves, MD, PhD, Laura Cunha Rodrigues, MD, PhD, Philip John Cooper, MD, PhD, Alvaro A. Cruz, MD, PhD, Lain Carlos Pontes-de-Carvalho, MD, PhD, Denise C. Lemaire, PhD, Ryan dos Santos Costa, MS, Leila D. Amorim, PhD, Candelaria Vergara, MD, PhD, Nicholas Rafaels, MS, Li Gao, MD, PhD, Cassandra Foster, Monica Campbell, BS, Rasika A. Mathias, ScD, Kathleen C. Barnes, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 6, Pages 1683-1690 (June 2013) DOI: 10.1016/j.jaci.2012.10.043 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Pairwise LD within Haploview by using the R′ squared statistic for the IL10 gene. Intensity of shading indicates the degree of confidence in the R′ value. Dark solid squares indicate an R′ value of 1. Untranslated regions are indicated by gray bars, exons by black bars, and introns by white bars. Exons are numbered from 5′ to 3′. Journal of Allergy and Clinical Immunology 2013 131, 1683-1690DOI: (10.1016/j.jaci.2012.10.043) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Functional analysis of IL-10 production according to the genotype for rs3024496. Box plot for IL-10 production for AA, AG, and GG genotypes for SNP rs3024496. Analysis is adjusted for sex, age, and principal components for ancestry informative markers (P = .05). Journal of Allergy and Clinical Immunology 2013 131, 1683-1690DOI: (10.1016/j.jaci.2012.10.043) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 DAG showing 2 causal paths between helminth infection and atopic asthma. The relationships observed were adjusted for sex, age, and ancestry informative markers. Journal of Allergy and Clinical Immunology 2013 131, 1683-1690DOI: (10.1016/j.jaci.2012.10.043) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions