Increased in vitro fitness of multi- and extensively drug-resistant F15/LAM4/KZN strains of Mycobacterium tuberculosis C.C. Naidoo, M. Pillay Clinical.

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Presentation transcript:

Increased in vitro fitness of multi- and extensively drug-resistant F15/LAM4/KZN strains of Mycobacterium tuberculosis C.C. Naidoo, M. Pillay Clinical Microbiology and Infection Volume 20, Issue 6, Pages O361-O369 (June 2014) DOI: 10.1111/1469-0691.12415 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Optical density (OD) measurements and CFU counts for competitive KZN strain pairs, (a) OD values and (b) CFU/mL for V9124 (S) +V1435 (MDR). (c) OD values and (d) CFU/mL for V9124 (S) + X162 (XDR). Data are represented as the mean ± SD of duplicate experiments. S: susceptible; MDR, multidrug-resistant; XDR, extensively drug-resistant. Clinical Microbiology and Infection 2014 20, O361-O369DOI: (10.1111/1469-0691.12415) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Mean competitive relative fitness for KZN, Beijing, F11 and F28 drug-resistant strains. The fitness index of the susceptible strain is taken as 1 (solid black line). Fitness indices below 1 indicate fitness costs and fitness indices above 1 indicate no loss of fitness. The data above are represented as the mean ± SD of duplicate experiments. MDR, multidrug-resistant; XDR, extensively drug-resistant. Clinical Microbiology and Infection 2014 20, O361-O369DOI: (10.1111/1469-0691.12415) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions