Novel baseline predictors of adverse events during oral immunotherapy in children with peanut allergy Yamini V. Virkud, MD, MA, MPH, A. Wesley Burks,

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Presentation transcript:

Novel baseline predictors of adverse events during oral immunotherapy in children with peanut allergy Yamini V. Virkud, MD, MA, MPH, A. Wesley Burks, MD, Pamela H. Steele, CPNP, Lloyd J. Edwards, PhD, Jelena P. Berglund, PhD, Stacie M. Jones, MD, Amy M. Scurlock, MD, Tamara T. Perry, MD, Robert D. Pesek, MD, Brian P. Vickery, MD Journal of Allergy and Clinical Immunology Volume 139, Issue 3, Pages 882-888.e5 (March 2017) DOI: 10.1016/j.jaci.2016.07.030 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Consort diagram of the study population. Journal of Allergy and Clinical Immunology 2017 139, 882-888.e5DOI: (10.1016/j.jaci.2016.07.030) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Frequencies of AEs, by symptoms reported, over the buildup and maintenance phases of OIT. Journal of Allergy and Clinical Immunology 2017 139, 882-888.e5DOI: (10.1016/j.jaci.2016.07.030) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Distributions of AEs, by month and by AR status. P < .001. Journal of Allergy and Clinical Immunology 2017 139, 882-888.e5DOI: (10.1016/j.jaci.2016.07.030) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Frequencies of AEs resulting in epinephrine use. Patterns of use of epinephrine concurrently with administration of antihistamines, albuterol, oral corticosteroids, or an ED visit (A), and in response to specific symptoms (cough, wheeze, hives, abdominal [Abd] pain, or vomiting) (B). Overlap of AEs with 2 or more given symptoms (ex: cough and wheeze) may be present. Journal of Allergy and Clinical Immunology 2017 139, 882-888.e5DOI: (10.1016/j.jaci.2016.07.030) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Histogram of rates and counts of AEs. Subjects A, B, and C experienced the top 3 highest counts of AEs, while subjects C, D, and E experienced the top 3 highest rates of AEs. Modeling the number of AEs based on the total count (left) captures the elevated amount of AEs experienced by individuals A, B, and C. Evaluating total counts, however, misses individuals D and E, who experienced low numbers of AEs over a short period of time, leading to early dropout. By adjusting for the time on therapy, modeling the rate of AEs (right) appropriately captures the experience of those individuals, like D and E, whose symptoms led them to discontinue OIT. Journal of Allergy and Clinical Immunology 2017 139, 882-888.e5DOI: (10.1016/j.jaci.2016.07.030) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions